Rho kinase as potential therapeutic target for cardiovascular diseases: opportunities and challenges

E Hu, D Lee - Expert Opinion on Therapeutic Targets, 2005 - Taylor & Francis
… but compelling evidence supporting the potential cardiovascular benefits of ROCK
inhibition in preclinical animal disease models and in the clinic. This review summarises the …

selective histone deacetylase isoforms as potential therapeutic targets in inflammatory bowel diseases

C Felice, A Lewis, A Armuzzi… - … & therapeutics, 2015 - Wiley Online Library
… Hence, we argue strongly for translational medical research focused on evaluating the
human … Other possible clinical implications of HDACs, such as fibrotic complications of CD or …

Inducible Co-Stimulator (ICOS) as a potential therapeutic target for anti-cancer therapy

F Amatore, L Gorvel, D Olive - Expert opinion on therapeutic targets, 2018 - Taylor & Francis
… Preclinical and clinical data have suggested a potential synergism between radiation therapy
and immunotherapy. Indeed, ionizing radiations might increase antigen release from dying …

[HTML][HTML] MiR-223-3p in cardiovascular diseases: a biomarker and potential therapeutic target

MW Zhang, YJ Shen, J Shi, JG Yu - Frontiers in Cardiovascular …, 2021 - frontiersin.org
… and effective biomarkers and therapeutic targets for CVDs are urgently needed. … potential
therapeutic target for CVDs and the miRNA-based therapeutic approaches to perform in clinical

Lysosomes in acute myeloid leukemia: potential therapeutic targets?

S Rafiq, SL McKenna, S Muller, MP Tschan, M Humbert - Leukemia, 2021 - nature.com
… of lysosomes, their potential role in the pathophysiology of malignant disease and consider
why lysosomes might represent a good therapeutic target for acute myeloid leukemia (AML). …

MYB oncoproteins: emerging players and potential therapeutic targets in human cancer

Y Cicirò, A Sala - Oncogenesis, 2021 - nature.com
… Broadly expressed transcription factors are considered unsuitable therapeutic targets
since their inactivation or downregulation could be detrimental to organism homoeostasis. …

Mechanisms of angiogenesis in vascular disorders: potential therapeutic targets

SA Mousa - Drugs of the Future, 1998 - access.portico.org
… that the effects are mediated by ribozyme cleavage of the target RNA. … hammerhead
ribozymes has considerable therapeutic potential. … Potential therapeutic targets for angiogenesis …

gp130 receptor ligands as potential therapeutic targets for obesity

MA Febbraio - The Journal of clinical investigation, 2007 - Am Soc Clin Investig
… of concomitantly decreasing body weight while enhancing insulin action that does not
induce adverse side effects such as those described above would have broad clinical impact. …

Many cytokines are very useful therapeutic targets in disease

M Feldmann - The Journal of clinical investigation, 2008 - Am Soc Clin Investig
… Their role as potential therapeutic targetstherapeutic targets, and the overwhelming message
is that “anti-cytokine medicine” is a rapidly growing field with major pharmaceutical impact. …

B cell lymphoma 2: a potential therapeutic target for cancer therapy

M Alam, S Ali, T Mohammad, GM Hasan… - International journal of …, 2021 - mdpi.com
… as a therapeutic target. We also discussed a comprehensive study of Bcl-2 inhibitors as a
therapeutic target for cancer therapy. This investigation summarizes the potential of Bcl-2-…