Epigenetic modifications as therapeutic targets

TK Kelly, DD De Carvalho, PA Jones - Nature biotechnology, 2010 - nature.com
Epigenetic changes often precede disease pathology, making them valuable diagnostic …
attention as potential therapeutic targets. The presence of multiple epigenetic aberrations within …

Epigenetic changes: potential therapeutic targets

T Kalebic - Annals of the New York Academy of Sciences, 2003 - Wiley Online Library
… Recognition of cancer-associated epigenetic patterns will be of critical importance for … and
therapeutic targets, as well as intermediate end points for monitoring the efficacy of therapeutic

Oxidative stress, autophagy, epigenetic changes and regulation by miRNAs as potential therapeutic targets in osteoarthritis

S Portal-Nunez, P Esbrit, MJ Alcaraz, R Largo - Biochemical pharmacology, 2016 - Elsevier
… Aging also interferes with epigenetic mechanisms such as activity of histone acetylases that
control … potential targets for the treatment of OA, a prevalent and therapeutic-orphan disease. …

A comprehensive study of epigenetic alterations in hepatocellular carcinoma identifies potential therapeutic targets

J Bayo, EJ Fiore, LM Dominguez, A Real… - Journal of …, 2019 - Elsevier
… between epigenetic alterations and hepatocarcinogenesis, indicating that epigenetic inhibition
may have therapeutic potential. We aimed to identify and target epigenetic modifiers that …

Epigenetic mechanisms and potential therapeutic targets in stroke

KC Morris-Blanco, AK Chokkalla… - Journal of Cerebral …, 2022 - journals.sagepub.com
epigenetic factors as therapeutic targets and biomarkers for stroke. Epigenetic mechanisms
… both the translational potential of epigenetic enzymes as therapeutic targets for stroke, as …

Epigenetic regulation in Alzheimer's disease: is it a potential therapeutic target?

F Coppedè - Expert Opinion on Therapeutic Targets, 2021 - Taylor & Francis
… This article examines the epigenetic modifications observed in AD tissues… changes in DNA
methylation and histone tail modifications, discussing their role as potential therapeutic targets

[HTML][HTML] The contribution and therapeutic potential of epigenetic modifications in Alzheimer's disease

IC Wood - Frontiers in neuroscience, 2018 - frontiersin.org
… ageing correlating with the timing of epigenetic changes occurring at a younger age in …
epigenetic changes may contribute to disease pathology. Exactly how epigenetic modifications

Epigenetic modifiers as potential therapeutic targets in diabetic kidney disease

JM Martinez-Moreno, M Fontecha-Barriuso… - International journal of …, 2020 - mdpi.com
Epigenetic regulators control gene expression and are potential therapeutic targets. There
… and the histone post-translational modifications—histone methylation, acetylation and …

Alzheimer's disease-related epigenetic changes: novel therapeutic targets

A Paniri, MM Hosseini, H Akhavan-Niaki - Molecular Neurobiology, 2024 - Springer
epigenetic modifications and factors on memory and plasticity throughout life, emphasizing
their potential as target for therapeutic … studies on abnormal epigenetics regulation in AD, as …

The role of selected epigenetic pathways in cardiovascular diseases as a potential therapeutic target

A Wołowiec, Ł Wołowiec, G Grześk, A Jaśniak… - International Journal of …, 2023 - mdpi.com
… targeted therapeutic interventions. The aim of the study was to present selected epigenetic
pathways, … diseases, and their potential as a therapeutic target in specific medical conditions. …