Epigenetic tools in potential anticancer therapy
K Sebova, I Fridrichova - Anti-cancer drugs, 2010 - journals.lww.com
… These changes, despite their heritability, could be reversible, raising the possibility of a new
therapeutic target. Epigenetic regulation of gene expression is essential for the diversity of …
therapeutic target. Epigenetic regulation of gene expression is essential for the diversity of …
Current limitations and future opportunities for epigenetic therapies
F Cherblanc, N Chapman-Rothe, R Brown… - Future medicinal …, 2012 - Taylor & Francis
… in epigenetic therapies that hope to … epigenetic changes, leading to changes in the expression
of genes involved in all the hallmarks of cancer. These epigenetic changes can potentially …
of genes involved in all the hallmarks of cancer. These epigenetic changes can potentially …
[HTML][HTML] Specific epigenetic regulators serve as potential therapeutic targets in idiopathic pulmonary fibrosis
M Sehgal, SM Jakhete, AG Manekar, S Sasikumar - Heliyon, 2022 - cell.com
… therapeutic compounds and their cellular targets to cure IPF. In this regard, a number of recent
studies have targeted the epigenetic … or dietary changes modulate dysregulated HDACs to …
studies have targeted the epigenetic … or dietary changes modulate dysregulated HDACs to …
[HTML][HTML] Modulating epigenetic modifications for cancer therapy
LJ Castro-Muñoz, EV Ulloa, C Sahlgren… - Oncology …, 2023 - spandidos-publications.com
… most promising therapeutic targets for treatment and reversal of drug resistance. Epigenetic
… The present review focuses on epigenetic reprogramming during tumorigenesis and recent …
… The present review focuses on epigenetic reprogramming during tumorigenesis and recent …
[HTML][HTML] Metabolism and epigenetic interplay in cancer: regulation and putative therapeutic targets
V Miranda-Gonçalves, A Lameirinhas… - Frontiers in …, 2018 - frontiersin.org
… Thus, epigenetics corresponds to heritable traits not involving alterations in DNA sequence,
… changes within the chromatin. The information conveyed by epigenetic modifications plays a …
… changes within the chromatin. The information conveyed by epigenetic modifications plays a …
Epigenetic therapy: targeting histones and their modifications in human disease
… future drug targets … epigenetic mechanism involving reversible acetylation. Hence, the
enzymes regulating reversible acetylation, particularly the HDACs, are potential therapeutic targets…
enzymes regulating reversible acetylation, particularly the HDACs, are potential therapeutic targets…
Epigenetic modifications as novel therapeutic targets for Huntington's disease
F Wang, PL Fischhaber, C Guo, TS Tang - Epigenomics, 2014 - Taylor & Francis
… We will mainly focus on DNA modifications including DNA methylation and … the existing
epigenetic targets for HD treatment and discuss the potential to develop therapeutic strategies …
epigenetic targets for HD treatment and discuss the potential to develop therapeutic strategies …
Targeting epigenetic modifications as a potential therapeutic option for diabetic retinopathy
N Kumari, A Karmakar… - Journal of cellular …, 2020 - Wiley Online Library
… epigenetic alterations associated with DR. However, the main focus is emphasized on
various epigenetic modifications … epigenetic inhibitors as a novel therapeutic option for DR. …
various epigenetic modifications … epigenetic inhibitors as a novel therapeutic option for DR. …
[HTML][HTML] Drugs targeting epigenetic modifications and plausible therapeutic strategies against colorectal cancer
S Patnaik, Anupriya - Frontiers in Pharmacology, 2019 - frontiersin.org
… evidences strongly suggest epigenetic modifications that contribute … This review covers
potential epigenetic modification … strong rationale to explore therapeutic strategies and provides a …
potential epigenetic modification … strong rationale to explore therapeutic strategies and provides a …
[HTML][HTML] Epigenetic modifications as therapeutic targets in atherosclerosis: a focus on DNA methylation and non-coding RNAs
H Sum, AC Brewer - Frontiers in Cardiovascular Medicine, 2023 - frontiersin.org
… represents a promising stem cell-based therapeutic strategy in the elusive struggle to reverse
the … be potential therapeutic targets for gene editing in this context. Alternatively, epigenetic …
the … be potential therapeutic targets for gene editing in this context. Alternatively, epigenetic …