Epigenetic tools in potential anticancer therapy

K Sebova, I Fridrichova - Anti-cancer drugs, 2010 - journals.lww.com
… These changes, despite their heritability, could be reversible, raising the possibility of a new
therapeutic target. Epigenetic regulation of gene expression is essential for the diversity of …

Current limitations and future opportunities for epigenetic therapies

F Cherblanc, N Chapman-Rothe, R Brown… - Future medicinal …, 2012 - Taylor & Francis
… in epigenetic therapies that hope to … epigenetic changes, leading to changes in the expression
of genes involved in all the hallmarks of cancer. These epigenetic changes can potentially

[HTML][HTML] Specific epigenetic regulators serve as potential therapeutic targets in idiopathic pulmonary fibrosis

M Sehgal, SM Jakhete, AG Manekar, S Sasikumar - Heliyon, 2022 - cell.com
therapeutic compounds and their cellular targets to cure IPF. In this regard, a number of recent
studies have targeted the epigenetic … or dietary changes modulate dysregulated HDACs to …

[HTML][HTML] Modulating epigenetic modifications for cancer therapy

LJ Castro-Muñoz, EV Ulloa, C Sahlgren… - Oncology …, 2023 - spandidos-publications.com
… most promising therapeutic targets for treatment and reversal of drug resistance. Epigenetic
… The present review focuses on epigenetic reprogramming during tumorigenesis and recent …

[HTML][HTML] Metabolism and epigenetic interplay in cancer: regulation and putative therapeutic targets

V Miranda-Gonçalves, A Lameirinhas… - Frontiers in …, 2018 - frontiersin.org
… Thus, epigenetics corresponds to heritable traits not involving alterations in DNA sequence,
changes within the chromatin. The information conveyed by epigenetic modifications plays a …

Epigenetic therapy: targeting histones and their modifications in human disease

A Gunjan, RK Singh - Future medicinal chemistry, 2010 - Taylor & Francis
… future drug targetsepigenetic mechanism involving reversible acetylation. Hence, the
enzymes regulating reversible acetylation, particularly the HDACs, are potential therapeutic targets

Epigenetic modifications as novel therapeutic targets for Huntington's disease

F Wang, PL Fischhaber, C Guo, TS Tang - Epigenomics, 2014 - Taylor & Francis
… We will mainly focus on DNA modifications including DNA methylation and … the existing
epigenetic targets for HD treatment and discuss the potential to develop therapeutic strategies …

Targeting epigenetic modifications as a potential therapeutic option for diabetic retinopathy

N Kumari, A Karmakar… - Journal of cellular …, 2020 - Wiley Online Library
epigenetic alterations associated with DR. However, the main focus is emphasized on
various epigenetic modificationsepigenetic inhibitors as a novel therapeutic option for DR. …

[HTML][HTML] Drugs targeting epigenetic modifications and plausible therapeutic strategies against colorectal cancer

S Patnaik, Anupriya - Frontiers in Pharmacology, 2019 - frontiersin.org
… evidences strongly suggest epigenetic modifications that contribute … This review covers
potential epigenetic modification … strong rationale to explore therapeutic strategies and provides a …

[HTML][HTML] Epigenetic modifications as therapeutic targets in atherosclerosis: a focus on DNA methylation and non-coding RNAs

H Sum, AC Brewer - Frontiers in Cardiovascular Medicine, 2023 - frontiersin.org
… represents a promising stem cell-based therapeutic strategy in the elusive struggle to reverse
the … be potential therapeutic targets for gene editing in this context. Alternatively, epigenetic