Advances in the proteomic discovery of novel therapeutic targets in cancer

S Guo, J Zou, G Wang - Drug design, development and therapy, 2013 - Taylor & Francis
… a potential therapeutic target to eradicate colon cancer stem cells contributing to colon cancer
… further investigated as a potential biomarker and therapeutic target for acquired resistance …

Cdc20: a potential novel therapeutic target for cancer treatment

Z Wang, L Wan, J Zhong, H Inuzuka… - Current …, 2013 - ingentaconnect.com
cancers. Furthermore, we summarize recent findings to indicate that Cdc20 may represent a
promising therapeutic target… useful for achieving better treatment outcome of cancer patients. …

RAL GTPases: biology and potential as therapeutic targets in cancer

C Yan, D Theodorescu - Pharmacological reviews, 2018 - ASPET
… RAL signaling as a potential therapeutic strategy for targeting RAS-driven human cancer. …
will be needed before they can be exploited as feasible therapeutic targets of RAL signaling. …

Mcl-1 is a potential therapeutic target in multiple types of cancer

C Akgul - Cellular and molecular life sciences, 2009 - Springer
… to promote apoptosis in cancer cells, suggesting that Mcl-1 can be a potential therapeutic
target in the treatment of several human malignancies. The figure shows the potential types of …

Validation of the Hsp70–Bag3 protein–protein interaction as a potential therapeutic target in cancer

X Li, T Colvin, JN Rauch, D Acosta-Alvear… - … cancer therapeutics, 2015 - AACR
Hsp70 is a stress-inducible molecular chaperone that is required for cancer development at
several steps. Targeting the active site of Hsp70 has proven relatively challenging, driving …

Osteopontin as a therapeutic target for cancer

M Bandopadhyay, A Bulbule, R Butti… - … on therapeutic targets, 2014 - Taylor & Francis
… OPN acts as a potential therapeutic target in a variety of cancers. It also acts as a prognostic
and diagnostic marker for several cancer types. Proteomic analyses have shown the …

CD200: a putative therapeutic target in cancer

J Moreaux, JL Veyrune, T Reme, J De Vos… - … and biophysical research …, 2008 - Elsevier
… Moreover, we show that CD200 expression is associated with tumor progression in various
cancers. Taken together, these data suggest that CD200 is a potential therapeutic target and …

Cell cycle kinases as therapeutic targets for cancer

S Lapenna, A Giordano - Nature reviews Drug discovery, 2009 - nature.com
… also being evaluated as potential new drug targets to improve cancer therapy. This Review
discusses the potential use of cell cycle protein kinases as therapeutic targets for cancer, and …

S100P: a novel therapeutic target for cancer

T Arumugam, CD Logsdon - Amino acids, 2011 - Springer
… different cancer models will be the subject of this review. We will also discuss the potential
benefit of developing new therapeutic agents to block the function of S100P on cancer tissue. …

Protein kinases and phosphatases as therapeutic targets in cancer

JJ Ventura, ÁR Nebreda - Clinical and Translational Oncology, 2006 - Springer
… inhibitors with proven or potential therapeutic value %r cancer treatment. These include
inhibitors of receptor and cytosolic tyrosine kinases as well as compounds that target difl'erent …