[HTML][HTML] Protein tyrosine phosphatases as potential therapeutic targets

R He, Z Yu, R Zhang, Z Zhang - Acta pharmacologica sinica, 2014 - nature.com
… It focuses on a disease-associated target with the goal of developing molecules modulating
target activity to provide potential therapeutics for disease treatment. In this process, target

[HTML][HTML] The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer?

MJ Duffy, M Mullooly, N O'Donovan, S Sukor, J Crown… - Clinical proteomics, 2011 - Springer
… The aim of this article is to review the role of ADAMs in malignancy, focusing especially on
their potential use as cancer biomarkers and therapeutic targets. Firstly however, we briefly …

Akt as a therapeutic target in cancer

LS Steelman, KM Stadelman… - … on therapeutic targets, 2008 - Taylor & Francis
… ERK and Akt are frequently activated in breast cancer specimens Citation[200,201].
Therefore, these pathways are therapeutic targets in breast and other cancers which exhibit …

[HTML][HTML] Emerging roles of SRSF3 as a therapeutic target for cancer

Z Zhou, Q Gong, Z Lin, Y Wang, M Li, L Wang… - Frontiers in …, 2020 - frontiersin.org
… Nevertheless, investigating the molecular mechanisms governing SRSF3-dependent signaling
will promisingly reveal new drug candidates and therapeutic targets for cancer treatment. …

MiR-29a: a potential therapeutic target and promising biomarker in tumors

J Wang, Q Zhang, D Wang, W Yan, H Sha… - Bioscience …, 2018 - portlandpress.com
potential therapeutic target and promising biomarker in various tumors. In this review, we
discussed the functions of miR-29a and its potential … serve as a potential therapeutic target and …

[HTML][HTML] Rho GTPases as therapeutic targets in cancer

GA Cardama, N González… - International …, 2017 - spandidos-publications.com
… The substantial body of evidence that relates Rho GTPases with cancer has made them an
attractive therapeutic target at the molecular level. With an incredible level of complexity and …

[HTML][HTML] Autophagy modulation as a potential therapeutic target for diverse diseases

DC Rubinsztein, P Codogno, B Levine - Nature reviews Drug discovery, 2012 - nature.com
… 9), thus raising the possibility that ageing and longevity may be therapeutic targets for …
paradigms that dictate our current understanding of autophagy as a target in cancer therapy. …

[HTML][HTML] Uncovering potential therapeutic targets in colorectal cancer by deciphering mutational status and expression of druggable oncogenes

O Menyhart, T Kakisaka, LS Pongor, H Uetake, A Goel… - Cancers, 2019 - mdpi.com
… of targeted therapies remains elusive. The … a potential approach for the identification of
therapeutic targets. We aimed to identify differentially expressed genes as potential drug targets

DJ-1 as a human oncogene and potential therapeutic target

J Cao, S Lou, M Ying, B Yang - Biochemical pharmacology, 2015 - Elsevier
… In addition, this study has identified DJ-1 as a potential tumor antigen found in the circulation
of breast cancer-bearing patients [25], and the level of DJ-1 in pancreatic juice is higher in …

Metabolic alterations of thyroid cancer as potential therapeutic targets

D Ciavardelli, M Bellomo, A Consalvo… - BioMed research …, 2017 - Wiley Online Library
… In the last decades, the study of cancer metabolism has gained great attention, aiming to
identify new potential therapeutic targets and early diagnostic or prognostic markers of …