… correlates with increased local release of matrix-degrading metalloproteinases (MMPs)
and weak fibrous cap tissue. These findings suggest a potential role of macrophage-derived …

… Matrix metalloproteinases (MMPs) are a family of structurally related zinc-dependent
endopeptidases collectively capable of degrading essentially all components of extracellular matrix …

… and represent an interesting target for therapeutic drug discovery. … Finally, we highlight MMPs
as promising therapeutic targets … investigated MMPs as potential therapeutic targets for the …

Introduction: This paper aims to summarize the scientific rationale and future perspectives in
the development of effective matrix metalloproteinase (MMP) modulators in the …

… The matrix metalloproteinase (MMP) family of enzymes is comprised of critically important
extracellular matrix remodeling proteases whose activity has been implicated in a number of …

… Extensive and compelling evidence indicates that several members of the matrix
metalloproteinase (MMP) family of enzymes play a key role in this regard and forms the rationale for …

… A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of
osteoarthritis: … , and orally active carboxylic acid based inhibitors of matrix metalloproteinase-13. J. …

… prevention is a therapeutic goal which has been difficult to achieve. Enzymes from the matrix
metalloproteinase and ADAMTS (a disintegrin, a metalloproteinase, and thrombospondin …

… Matrix metalloproteinases (MMPs) serve crucial roles in both pathogenesis and wound
healing. The primary functions of MMPs are degradation, which involves removing the disrupted …

Introduction: MMPs are zinc-dependent endopeptidases that play a key role in the remodeling
of extracellular matrix (ECM). Various pathogenic mediators trigger abnormal MMP activity …