The role and mechanism of pyroptosis and potential therapeutic targets in sepsis: a review

X Zheng, W Chen, F Gong, Y Chen, E Chen - Frontiers in immunology, 2021 - frontiersin.org
… in sepsis can control pathogen infection, excessive pyroptosis can lead to a dysregulated …
overview of the mechanisms and potential therapeutic targets underlying pyroptosis in sepsis …

Pyroptosis and its role in autoimmune disease: a potential therapeutic target

R You, X He, Z Zeng, Y Zhan, Y Xiao… - Frontiers in …, 2022 - frontiersin.org
… -independent pathway, are also described. We highlight the recent advances in pyroptosis
in … its potential advantages as a therapeutic target or prognostic marker in these diseases. …

Inflammasomes and pyroptosis as therapeutic targets for COVID-19

JKY Yap, M Moriyama, A Iwasaki - The Journal of Immunology, 2020 - journals.aai.org
… pharmaceutical agents that target a critical component of inflammasome activation, signaling
leading to cellular pyroptosis, and the downstream cytokines as a promising target for the …

Pyroptosis: a promising therapeutic target for noninfectious diseases

T Li, G Zheng, B Li, L Tang - Cell proliferation, 2021 - Wiley Online Library
pyroptotic signalling pathway is of great interest. In this review, we will address the pathogenic
role of pyroptosis in … the current therapeutic strategies that target pyroptotic proteins and …

Ubiquitination in pyroptosis pathway: A potential therapeutic target for sepsis

Y Liao, W Zhang, M Zhou, C Zhu, Z Zou - Cytokine & Growth Factor …, 2024 - Elsevier
… on the molecular mechanisms of ubiquitination within pyroptoticpyroptosis and its associated
inflammatory signaling pathways, this review provides insights into potential therapeutic

Targeted pyroptosis is a potential therapeutic strategy for cancer

H Wu, D Qian, X Bai, S Sun - Journal of Oncology, 2022 - Wiley Online Library
… , and curcumin have effect on these cancers and simultaneously promote the pyroptosis
of cancer cells. Accordingly, pyroptosis may be an important therapeutic target for cancer. …

Emerging mechanisms of pyroptosis and its therapeutic strategy in cancer

L Lu, Y Zhang, X Tan, Y Merkher, S Leonov, L Zhu… - Cell death …, 2022 - nature.com
… SNHG7 is upregulated in HCC and contributes to NLRP3-dependent pyroptosis via the
miR-34a/SIRT1 axis [59]. Thus, the inflammasome may be a potential therapeutic target for HCC. …

Pyroptosis: a newly discovered therapeutic target for ischemia-reperfusion injury

Y Zheng, X Xu, F Chi, N Cong - Biomolecules, 2022 - mdpi.com
… the mechanisms of pyroptosis and its role as a potential therapeutic target for I/R injury. …
This section discusses the role of pyroptosis in I/R injury in different organs and possible

Pyroptosis as a candidate therapeutic target for Alzheimer's disease

Y Huang, X Li, G Luo, J Wang, R Li, C Zhou… - Frontiers in Aging …, 2022 - frontiersin.org
… This paper focuses on elucidating the mechanisms of pyroptosis-… pyroptosis in AD therapy.
It is well-known that inflammasome NLRP1, NLRP3, NLRP4, and AIM2 can initiate pyroptosis-…

TI: NLRP3 inflammasome-dependent pyroptosis in CNS trauma: a potential therapeutic target

C Zhou, J Zheng, Y Fan, J Wu - Frontiers in cell and developmental …, 2022 - frontiersin.org
… Here, we focus on the molecular mechanisms of NLRP3 inflammasome in the pyroptosis
signaling pathway, including its prime, activation, and post-translational modifications. Moreover…