… diagnosis, treatment, and management of patients with sepsis. … pathogenesis and the target
of clinical diagnosis of sepsis, with the goal of enhancing the current understanding of sepsis…

… knowledge of sepsis pathogenesis and potential novel approaches to the treatment of this …
PD1–PDL1 axis as a potential therapeutic target in sepsis 42 . Monocyte PDL1 expression is …

… Additionally, we highlight important targets involved in sepsis-related regulatory … in potential
therapeutic drugs that specifically target these signaling pathways and paramount targets, …

… In summary, while the innate immune system is rich in potential therapeutic targets and
remains a promising area of research, as has been demonstrated by the study of cytokines in this …

… mechanisms underlying sepsis and to identify potential therapeutic targets and compounds.
… the prospective therapeutic properties of Danshen in a range of diseases, including sepsis. …

… actions in recent years, a number of therapeutic strategies targeting cytokines and other …
septic patients. Their current role in the treatment of sepsis is discussed later in this review. …

… Finally, we highlight recently described inhibitors of cytosolic LPS-triggered noncanonical
inflammasome activation that might be considered as potential drugs for the treatment of sepsis…

… We hope the discussion of such studies provides not only new insight into the pathobiology
of sepsis, but also suggests possible therapeutic targets for the management of this …

… Thus, strategies focusing on further therapy targets are an important area of interest …
pathogenesis of sepsis, focusing on recent advances and on possible targets for adjunctive therapy. …

… evolution of sepsis therapy (Table 1) and identifies possible causes for why rational therapies
failed in human trials. In addition, this article examines potential future sepsis targets and …