The angiopoietin-Tie2 system as a therapeutic target in sepsis and acute lung injury

M van der Heijden… - … on therapeutic targets, 2009 - Taylor & Francis
… This review focuses on the role of angiopoietins in the pathophysiology of sepsis and ALI/ARDS.
All original experimental and patient studies on angiopoietins and sepsis/endotoxemia, …

Long non-coding RNAs as biomarkers and therapeutic targets in sepsis

C Wang, G Liang, J Shen, H Kong, D Wu… - Frontiers in …, 2021 - frontiersin.org
… the body more susceptible to pathogenic infection (29). Hence, clear diagnosis and
effective treatment during the early phase of sepsis will significantly improve clinical outcomes. …

[HTML][HTML] Sepsispathophysiology and therapeutic concepts

D Jarczak, S Kluge, A Nierhaus - Frontiers in medicine, 2021 - frontiersin.org
… an overview of sepsis immune pathophysiology, to update the choice of therapeutic approaches
targeting different immunological mechanisms in the course of sepsis and septic shock, …

Clinical application: Restoration of immune homeostasis by autophagy as a potential therapeutic target in sepsis

L Zhang, Y Ai, A Tsung - Experimental and therapeutic …, 2016 - spandidos-publications.com
… in sepsis may significantly impair B and T cell function (18). Therefore, inhibition of apoptosis
has served as a therapeutic target for sepsis. … experiments provide potential therapies that …

Circulating histones in sepsis: potential outcome predictors and therapeutic targets

Y Li, D Wan, X Luo, T Song, Y Wang, Q Yu… - Frontiers in …, 2021 - frontiersin.org
… been laid on identifying novel therapeutic targets and prognostic biomarkers for sepsis
of sepsis, and confirms CHs’ potential as therapeutic targets in future sepsis management. …

HSP-target of therapeutic agents in sepsis treatment

A Vulczak, CHR Catalão, LAP Freitas… - International Journal of …, 2019 - mdpi.com
sepsis models. In this review, we present the main results of studies on therapeutic agents in
targeting HSPs in sepsis treatment. We … As a therapeutic targets, HSPs have aroused great …

Therapeutic targets and signaling mechanisms of vitamin C activity against sepsis: a bioinformatics study

R Li, C Guo, Y Li, Z Qin, W Huang - Briefings in bioinformatics, 2021 - academic.oup.com
… effectively highlighted potential therapeutic targets, BPs and pharmacological pathways of
VC action against sepsis. The bioinformatics data presented identify potential targets that may …

Therapeutic targets for sepsis

L Sorbera, C Dulsat, E Rosa - Drugs of the Future, 2009 - access.portico.org
… To date, treatment for sepsis consists of eradication of infection through early and … presents
those drug targets that are currently under active investigation for the treatment of sepsis. …

Therapeutic potential of extracellular vesicles for sepsis treatment

SM Kronstadt, AE Pottash, D Levy, S Wang… - … therapeutics, 2021 - Wiley Online Library
… Consequently, the inhibition of ER stress has been recognized as a viable therapeutic
target for sepsis with the demonstrated ability to attenuate apoptosis as well as inflammation in …

Pathophysiology of sepsis in the elderly: clinical impact and therapeutic considerations

AR De Gaudio, S Rinaldi, C Chelazzi… - … drug targets, 2009 - ingentaconnect.com
pathogenetic differences of sepsis in the elderly that can increase its incidence and mortality,
with emphasis on the immunologic changes, clinical impact and possible new therapeutic