Pre-existing helminth infection impairs the efficacy of adjuvanted influenza vaccination in mice

W Hartmann, ML Brunn, N Stetter, G Gabriel, M Breloer - Plos one, 2022 - journals.plos.org
… -water squalene-based adjuvant that is licensed for humans [… vaccination with the non-adjuvanted
influenza vaccine Begripal or single vaccination with the adjuvanted influenza vaccine

Helminth infections suppress the efficacy of vaccination against seasonal influenza

W Hartmann, ML Brunn, N Stetter, N Gagliani… - Cell reports, 2019 - cell.com
pre-existing Schistosoma mansoni or any intestinal helminth … , a non-adjuvanted
trivalent split subunit vaccine that is … time between seasonal influenza vaccination and “challenge” …

A combination of deworming and prime-boost vaccination regimen restores efficacy of vaccination against influenza in helminth-infected mice

N Stetter, W Hartmann, ML Brunn… - Frontiers in …, 2021 - frontiersin.org
… with influenza vaccination or two weeks before influenza … -boost vaccination with the
non-adjuvanted vaccine Begripal or … that pre-existing helminth-infections impair the efficacy of …

[HTML][HTML] Filarial infections compromise influenza vaccination efficacy: Lessons from the mouse

M Breloer, W Hartmann - Immunology Letters, 2023 - Elsevier
… a negative correlation between pre-existing helminth infections and responses to … past
helminth infection impairs vaccination efficacy. A: A single non-adjuvanted influenza vaccination

[HTML][HTML] Do parasite infections interfere with immunisation? A review and meta-analysis

LF Wait, AP Dobson, AL Graham - Vaccine, 2020 - Elsevier
Adjuvants, by increasing vaccine immunogenicity, may also … For example, mice with
pre-existing orthopoxvirus immunity … to influenza vaccination, but when challenged with influenza

Soil-transmitted helminth vaccines: are we getting closer?

A Zawawi, KJ Else - Frontiers in immunology, 2020 - frontiersin.org
… other control measures, helminth infections are spreading into … However, recombinant
vaccines often require an adjuvant … of pre-existing chronic infections. Despite an increase in STH …

A new role for old friends: effects of helminth infections on vaccine efficacy

F Zhu, W Liu, T Liu, L Shi, W Zheng, F Guan, J Lei - Pathogens, 2022 - mdpi.com
… regarding vaccines themselves, such as type, adjuvant, … influenza-specific antibodies than
vaccinated naïve control mice [48]. Both these data suggest that basic influenza vaccination

Immunogenicity of influenza vaccines: evidence for differential effect of secondary vaccination on humoral and cellular immunity

SK Rosendahl Huber, M Hendriks, RHJ Jacobi… - Frontiers in …, 2019 - frontiersin.org
… by both MF59-adjuvanted and unadjuvanted subunit influenza vaccines. We performed …
for possible confounders, such as pre-existing immunity due to influenza virus infection and …

Immunological Considerations for Schistosoma Vaccine Development: Transitioning to Endemic Settings

E Driciru, JPR Koopman, S Cose, AA Siddiqui… - Frontiers in …, 2021 - frontiersin.org
… In addition, booster regimens, potent adjuvants and higher … of albendazole treatment on
influenza vaccine response, despite … treatment of intense pre-existing infection which results in …

Age and influenza-specific pre-vaccination antibodies strongly affect influenza vaccine responses in the Icelandic population whereas disease and medication have …

TA Olafsdottir, KF Alexandersson… - Frontiers in …, 2018 - frontiersin.org
… antigenic distances between annual vaccine strains on one … Pre-existing immunity has
also been shown to affect the type of antibodies induced upon vaccination with low-pre-existing