Genome, epigenome, and transcriptome editing via chemical modification of nucleobases in living cells

BL Ranzau, AC Komor - Biochemistry, 2018 - ACS Publications
… manner, allowing for genome, epigenome, and transcriptome editing in live cells. These tools
… The efficiency and precision of base editors makes them useful in both basic research and …

[HTML][HTML] Synthetic lethality-mediated precision oncology via the tumor transcriptome

JS Lee, NU Nair, G Dinstag, L Chapman, Y Chung… - Cell, 2021 - cell.com
… will benefit from genomics-guided precision treatments. … precision oncology framework,
SELECT (synthetic lethality and rescue-mediated precision oncology via the transcriptome

Omics, big data, and precision medicine in cardiovascular sciences

E Lau, JC Wu - Circulation research, 2018 - Am Heart Assoc
… The transcriptome offers further intriguing clues to the functions of genetic variants. Unlike
the genome, the transcriptome is highly dynamic in response to acute and cumulative …

Concepts and methods for transcriptome-wide prediction of chemical messenger RNA modifications with machine learning

P Acera Mateos, Y Zhou, K Zarnack… - Briefings in …, 2023 - academic.oup.com
… While m6Anet shows higher accuracy than Nanom6A [74] and EpiNano [64] using an in
vivo HEK293 dataset, it only identifies m6A sites in DRACH motifs and has a low precision. …

Can metabolic profiles be used as a phenotypic readout of the genome to enhance precision medicine?

K Contrepois, L Liang, M Snyder - Clinical chemistry, 2016 - academic.oup.com
… remain, the combined use of metabolomic and genomic data has the potential to … genomes
will be sequenced and metabolomes (as well as potentially other omes such as transcriptome

Microfluidic single-cell whole-transcriptome sequencing

AM Streets, X Zhang, C Cao, Y Pang… - Proceedings of the …, 2014 - National Acad Sciences
… the chemistry in a microfluidic platform for single-cell whole-… To quantitatively evaluate the
sensitivity and precision of our … genome, like the mouse or the human reference genome, and …

Whole-genome mapping of small-molecule targets for cancer medicine

S Solier, S Müller, R Rodriguez - Current Opinion in Chemical Biology, 2020 - Elsevier
… whole-genome and transcriptome level using … genomic level by targeting DNA or chromatin
proteins. Here, we review recent advances in establishing whole-genome and transcriptome

Single‐cell sequencing methodologies: from transcriptome to multi‐dimensional measurement

Y Chen, J Song, Q Ruan, X Zeng, L Wu, L Cai… - Small …, 2021 - Wiley Online Library
… Full-length scRNA-seq methods examine the genome-wide transcriptome, holding promise
precise isolation of single cells from defined anatomical locations and global transcriptome

ProteomeGenerator: a framework for comprehensive proteomics based on de novo transcriptome assembly and high-accuracy peptide mass spectral matching

P Cifani, A Dhabaria, Z Chen, A Yoshimi… - Journal of proteome …, 2018 - ACS Publications
… Having obtained genome-scale mass spectrometry data and the transcriptome-derived
PGX database, we next sought to confirm accuracy of algorithms for scoring peptide–spectral …

[HTML][HTML] Omics-based strategies in precision medicine: toward a paradigm shift in inborn errors of metabolism investigations

A Tebani, C Afonso, S Marret, S Bekri - International journal of molecular …, 2016 - mdpi.com
genomic landscape. HTS techniques can be classified according to their applications for
investigating genomes, epigenomes, or transcriptome. … , especially for capture chemistry-based …