Genome, epigenome, and transcriptome editing via chemical modification of nucleobases in living cells
… manner, allowing for genome, epigenome, and transcriptome editing in live cells. These tools
… The efficiency and precision of base editors makes them useful in both basic research and …
… The efficiency and precision of base editors makes them useful in both basic research and …
[HTML][HTML] Synthetic lethality-mediated precision oncology via the tumor transcriptome
… will benefit from genomics-guided precision treatments. … precision oncology framework,
SELECT (synthetic lethality and rescue-mediated precision oncology via the transcriptome…
SELECT (synthetic lethality and rescue-mediated precision oncology via the transcriptome…
Omics, big data, and precision medicine in cardiovascular sciences
… The transcriptome offers further intriguing clues to the functions of genetic variants. Unlike
the genome, the transcriptome is highly dynamic in response to acute and cumulative …
the genome, the transcriptome is highly dynamic in response to acute and cumulative …
Concepts and methods for transcriptome-wide prediction of chemical messenger RNA modifications with machine learning
… While m6Anet shows higher accuracy than Nanom6A [74] and EpiNano [64] using an in
vivo HEK293 dataset, it only identifies m6A sites in DRACH motifs and has a low precision. …
vivo HEK293 dataset, it only identifies m6A sites in DRACH motifs and has a low precision. …
Can metabolic profiles be used as a phenotypic readout of the genome to enhance precision medicine?
… remain, the combined use of metabolomic and genomic data has the potential to … genomes
will be sequenced and metabolomes (as well as potentially other omes such as transcriptome …
will be sequenced and metabolomes (as well as potentially other omes such as transcriptome …
Microfluidic single-cell whole-transcriptome sequencing
… the chemistry in a microfluidic platform for single-cell whole-… To quantitatively evaluate the
sensitivity and precision of our … genome, like the mouse or the human reference genome, and …
sensitivity and precision of our … genome, like the mouse or the human reference genome, and …
Whole-genome mapping of small-molecule targets for cancer medicine
S Solier, S Müller, R Rodriguez - Current Opinion in Chemical Biology, 2020 - Elsevier
… whole-genome and transcriptome level using … genomic level by targeting DNA or chromatin
proteins. Here, we review recent advances in establishing whole-genome and transcriptome …
proteins. Here, we review recent advances in establishing whole-genome and transcriptome …
Single‐cell sequencing methodologies: from transcriptome to multi‐dimensional measurement
Y Chen, J Song, Q Ruan, X Zeng, L Wu, L Cai… - Small …, 2021 - Wiley Online Library
… Full-length scRNA-seq methods examine the genome-wide transcriptome, holding promise
… precise isolation of single cells from defined anatomical locations and global transcriptome …
… precise isolation of single cells from defined anatomical locations and global transcriptome …
ProteomeGenerator: a framework for comprehensive proteomics based on de novo transcriptome assembly and high-accuracy peptide mass spectral matching
… Having obtained genome-scale mass spectrometry data and the transcriptome-derived
PGX database, we next sought to confirm accuracy of algorithms for scoring peptide–spectral …
PGX database, we next sought to confirm accuracy of algorithms for scoring peptide–spectral …
[HTML][HTML] Omics-based strategies in precision medicine: toward a paradigm shift in inborn errors of metabolism investigations
… genomic landscape. HTS techniques can be classified according to their applications for
investigating genomes, epigenomes, or transcriptome. … , especially for capture chemistry-based …
investigating genomes, epigenomes, or transcriptome. … , especially for capture chemistry-based …