Transcriptomics: advances and approaches

ZC Dong, Y Chen - Science China Life Sciences, 2013 - Springer
genome has been sequenced, transcriptome analysis allows us to understand the expression
of genome … observed globally in higher throughput and more precise level (Table 1) [53]. …

The impact of whole genome and transcriptome analysis (WGTA) on predictive biomarker discovery and diagnostic accuracy of advanced malignancies

B Tessier‐Cloutier, JK Grewal… - The Journal of …, 2022 - Wiley Online Library
… form the foundation of precision oncology. The profound … Genome Sciences Centre, and
sequenced on Illumina platforms (San Diego, CA, USA): HiSeq 2500 using V3 or V4 chemistry

RNA‐Seq methods for transcriptome analysis

R Hrdlickova, M Toloue, B Tian - Wiley Interdisciplinary …, 2017 - Wiley Online Library
… , providing single base-level precision for our understanding of nucleic acid … genome-wide,
the requirement that a priori sequence information or reference genomes/transcriptomes be …

[HTML][HTML] High-throughput transcriptome profiling in drug and biomarker discovery

X Yang, L Kui, M Tang, D Li, K Wei, W Chen… - Frontiers in …, 2020 - frontiersin.org
… As described above, HTS is very powerful and cost-efficient tool for genome-wide transcriptome
… In a word, transcriptome analysis with scRNA-seq provides more precise insights into …

[HTML][HTML] Applications and potentials of nanopore sequencing in the (epi) genome and (epi) transcriptome era

S Xie, AWS Leung, Z Zheng, D Zhang, C Xiao, R Luo… - The Innovation, 2021 - cell.com
… biological research into the genomic and post-genomic era. The success of the Human Genome
Project (HGP… The HPG started in 1990 and its first draft genome was published in 2001, …

Characterization and improvement of RNA-Seq precision in quantitative transcript expression profiling

PP Łabaj, GG Leparc, BE Linggi, LM Markillie… - …, 2011 - academic.oup.com
… of target identification and measurement precision, including their … on only 7% of the known
transcriptome, however, making less … of splice junctions and allows genome-wide qualitative …

Properties and reactivity of nucleic acids relevant to epigenomics, transcriptomics, and therapeutics

D Gillingham, S Geigle, OA Von Lilienfeld - Chemical Society Reviews, 2016 - pubs.rsc.org
… rely on a precise understanding of nucleic acid properties and … to deconstruct the enormously
complex transcriptome. … bases in whole genomes and transcriptomes at single nucleotide …

[HTML][HTML] The need for multi-omics biomarker signatures in precision medicine

M Olivier, R Asmis, GA Hawkins, TD Howard… - International journal of …, 2019 - mdpi.com
precision medicine approach is equated with a genomics approach. This is likely due to the
fact that genomic … potential mechanism by which the transcriptome could have been altered. …

Rapid transcriptome characterization for a nonmodel organism using 454 pyrosequencing

JC Vera, CW Wheat, HW Fescemyer… - Molecular …, 2008 - Wiley Online Library
… Although a precise estimate of transcriptome coverage is unattainable without full genomic
… more, of the Melitaea cinxia transcriptome. Xenobiotic sequences were also detected and …

Genomics, other “OMIC” technologies, precision medicine, and additional biotechnology-related techniques

RD Sindelar - Pharmaceutical Biotechnology: Fundamentals and …, 2024 - Springer
… (miRNAs) are part of the transcriptome and are described in detail in our chapter … transcriptome
can vary within individual cells with external environmental conditions, while the genome