Advances and challenges in epigenomic single-cell sequencing applications

M Philpott, AP Cribbs, T Brown Jr, T Brown Sr… - … Opinion in Chemical …, 2020 - Elsevier
… critical features such as transcriptomes, epigenomes, … would ultimately allow the
precise definition of cellular states. … and transcriptome profiling was single-cell genome-wide …

[HTML][HTML] Deep neural network prediction of genome-wide transcriptome signatures–beyond the Black-box

R Magnusson, JN Tegnér, M Gustafsson - NPJ systems biology and …, 2022 - nature.com
… We provide the average precision- and receiver operating characteristic scores, with the
corresponding figures, in the Supplemental Material 2. We defined accuracy as the percentage …

Understanding the transcriptome through RNA structure

Y Wan, M Kertesz, RC Spitale, E Segal… - Nature Reviews …, 2011 - nature.com
… To close this gap, genome-… and precision of genomic data. High-throughput sequencing
has been successfully applied in many applications, including genome discovery, transcriptome

CRISPRi and CRISPRa screens in mammalian cells for precision biology and medicine

M Kampmann - ACS chemical biology, 2018 - ACS Publications
… a massive accumulation of genomic and transcriptomic data … of the human genome and
transcriptome, and implications for … , and single-cell transcriptomes. Combinatorial screens, in …

[HTML][HTML] Fast-acting chemical tools to delineate causality in transcriptional control

MG Jaeger, GE Winter - Molecular cell, 2021 - cell.com
… mechanistic insights from time-resolved genomics studies. Showcasing advances in multi-…
Because of this framework’s contingency on fast and precise perturbation, chemical tools …

Genome and transcriptome engineering by compact and versatile CRISPR-Cas systems

G Aquino-Jarquin - Drug Discovery Today, 2023 - Elsevier
precise genome and transcriptomeprecision (the fraction of on-target edits that leads to
the expected genetic outcome) are two critical aspects determining the clinical utility of genome

A guide for bioinformaticians:'omics-based drug discovery for precision oncology

J Mun, G Choi, B Lim - Drug discovery today, 2020 - Elsevier
… human genomes per run at a cost of < S$1000 per genome. … We briefly present a practical
use of transcriptome-based … with medicinal chemists to modify chemical motifs and satisfy …

Transcriptome-wide profiling of multiple RNA modifications simultaneously at single-base resolution

V Khoddami, A Yerra, TL Mosbruger… - Proceedings of the …, 2019 - National Acad Sciences
… Detection of each of these modifications through a unique chemistry allows high-precision
the RefSeq transcript positions were converted to genomic positions using the python hgvs …

[HTML][HTML] Single cell genomics: advances and future perspectives

IC Macaulay, T Voet - PLoS genetics, 2014 - journals.plos.org
… Advances in whole-genome and whole-transcriptome … extent and nature of genomic and
transcriptomic heterogeneity … Secondly, sequencing provides digital precision, with one digital …

[HTML][HTML] Transcriptome response to pollutants and insecticides in the dengue vector Aedes aegypti using next-generation sequencing technology

JP David, E Coissac, C Melodelima, R Poupardin… - BMC genomics, 2010 - Springer
… -lethal doses of three chemical insecticides and three anthropogenic pollutants. … transcriptome
coverage together with a higher number of cDNA tags per gene, leading to more precise