Advances and challenges in epigenomic single-cell sequencing applications
M Philpott, AP Cribbs, T Brown Jr, T Brown Sr… - … Opinion in Chemical …, 2020 - Elsevier
… critical features such as transcriptomes, epigenomes, … would ultimately allow the
precise definition of cellular states. … and transcriptome profiling was single-cell genome-wide …
precise definition of cellular states. … and transcriptome profiling was single-cell genome-wide …
[HTML][HTML] Deep neural network prediction of genome-wide transcriptome signatures–beyond the Black-box
… We provide the average precision- and receiver operating characteristic scores, with the
corresponding figures, in the Supplemental Material 2. We defined accuracy as the percentage …
corresponding figures, in the Supplemental Material 2. We defined accuracy as the percentage …
Understanding the transcriptome through RNA structure
… To close this gap, genome-… and precision of genomic data. High-throughput sequencing
has been successfully applied in many applications, including genome discovery, transcriptome …
has been successfully applied in many applications, including genome discovery, transcriptome …
CRISPRi and CRISPRa screens in mammalian cells for precision biology and medicine
M Kampmann - ACS chemical biology, 2018 - ACS Publications
… a massive accumulation of genomic and transcriptomic data … of the human genome and
transcriptome, and implications for … , and single-cell transcriptomes. Combinatorial screens, in …
transcriptome, and implications for … , and single-cell transcriptomes. Combinatorial screens, in …
[HTML][HTML] Fast-acting chemical tools to delineate causality in transcriptional control
… mechanistic insights from time-resolved genomics studies. Showcasing advances in multi-…
Because of this framework’s contingency on fast and precise perturbation, chemical tools …
Because of this framework’s contingency on fast and precise perturbation, chemical tools …
Genome and transcriptome engineering by compact and versatile CRISPR-Cas systems
G Aquino-Jarquin - Drug Discovery Today, 2023 - Elsevier
… precise genome and transcriptome … precision (the fraction of on-target edits that leads to
the expected genetic outcome) are two critical aspects determining the clinical utility of genome …
the expected genetic outcome) are two critical aspects determining the clinical utility of genome …
A guide for bioinformaticians:'omics-based drug discovery for precision oncology
… human genomes per run at a cost of < S$1000 per genome. … We briefly present a practical
use of transcriptome-based … with medicinal chemists to modify chemical motifs and satisfy …
use of transcriptome-based … with medicinal chemists to modify chemical motifs and satisfy …
Transcriptome-wide profiling of multiple RNA modifications simultaneously at single-base resolution
V Khoddami, A Yerra, TL Mosbruger… - Proceedings of the …, 2019 - National Acad Sciences
… Detection of each of these modifications through a unique chemistry allows high-precision …
the RefSeq transcript positions were converted to genomic positions using the python hgvs …
the RefSeq transcript positions were converted to genomic positions using the python hgvs …
[HTML][HTML] Single cell genomics: advances and future perspectives
IC Macaulay, T Voet - PLoS genetics, 2014 - journals.plos.org
… Advances in whole-genome and whole-transcriptome … extent and nature of genomic and
transcriptomic heterogeneity … Secondly, sequencing provides digital precision, with one digital …
transcriptomic heterogeneity … Secondly, sequencing provides digital precision, with one digital …
[HTML][HTML] Transcriptome response to pollutants and insecticides in the dengue vector Aedes aegypti using next-generation sequencing technology
… -lethal doses of three chemical insecticides and three anthropogenic pollutants. … transcriptome
coverage together with a higher number of cDNA tags per gene, leading to more precise …
coverage together with a higher number of cDNA tags per gene, leading to more precise …