Preclinical in Vivo Activity of 2′,2′-Difluorodeoxycytidine (Gemcitabine) against Human Head and Neck Cancer

BJM Braakhuis, GAMS van Dongen, JB Vermorken… - Cancer research, 1991 - AACR
… good antitumor activity of dFdCyd. In this respect, we could show that the activity of deoxycytidine
… This study was performed in head and neck cancer xenografts; enzyme activity varied …

Preclinical activity of ribociclib in squamous cell carcinoma of the head and neck

G Van Caloen, S Schmitz, M El Baroudi… - Molecular cancer …, 2020 - AACR
… In this work, we investigated the activity of ribociclib in several HPV-negative and HPV-positive
preclinical SCCHN models with the aim of identifying predictive biomarkers of response. …

Preclinical models in HNSCC: A comprehensive review

B Méry, C Rancoule, JB Guy, S Espenel, AS Wozny… - Oral oncology, 2017 - Elsevier
… and genetic investigations in head and neck cancer and tests in a … This review focuses on
the most pertinent preclinical models of … preclinical model depending on the aim of the study. …

[HTML][HTML] Precision medicine in head and neck cancers: genomic and preclinical approaches

G Miserocchi, C Spadazzi, S Calpona… - Journal of Personalized …, 2022 - mdpi.com
… effects of personalised treatments, preclinical research can take … Preclinical research has
constantly implemented in vitro and … approaches aimed to improve preclinical tools to study and …

[HTML][HTML] Preclinical models in head and neck squamous cell carcinoma

P Chaves, M Garrido, J Oliver, E Pérez-Ruiz… - British Journal of …, 2023 - nature.com
… the development of reliable preclinical models essential for the … Preclinical models of head
and neck squamous cell … In this review, we will go over the most frequently used preclinical

[HTML][HTML] Preclinical models of head and neck squamous cell carcinoma for a basic understanding of cancer biology and its translation into efficient therapies

I Tinhofer, D Braunholz, K Klinghammer - Cancers of the Head & Neck, 2020 - Springer
Head and neck cancer is the seventh most common cancer … Reliable preclinical models
are therefore critical to better … This review describes the mostly used preclinical models of …

Preclinical antitumor activity of 5-aza-2′-deoxycytidine agains human head and neck cancer xenografts

BJM Braakhuis, GAMS van Dongen… - Investigational new …, 1988 - Springer
… In general, the activity of anticancer drugs in the nude mouse correlates with the clinical …
dCyd shows activity in head and neck cancer xenografts. Evidence is provided that the activity of …

Preclinical chemotherapy on human head and neck cancer xenografts grown in athymic nude mice

BJM Braakhuis, GAMS Van Dongen, M Bagnay… - Head & …, 1989 - Wiley Online Library
activity in all four HNSCC lines tested. A number of experimental drugs that have promising
preclinical activity … (1 0-MAM) showed activity in three of five, and two of the four tested tumor …

[HTML][HTML] Combined effects of bevacizumab with erlotinib and irradiation: a preclinical study on a head and neck cancer orthotopic model

A Bozec, A Sudaka, JL Fischel, MC Brunstein… - British journal of …, 2008 - nature.com
… , was assessed in a VEGF-secreting human head and neck tumour cell line, CAL33, that …
head and neck cancer xenograft model consisting in injecting CAL33, a human head and neck

[HTML][HTML] Targeted treatment of head and neck (pre) cancer: preclinical target identification and development of novel therapeutic applications

AM van Harten, RH Brakenhoff - Cancers, 2021 - mdpi.com
… This review focusses on the preclinical identification of … The molecular landscape of head
and neck cancer has been … the current literature on the preclinical identification of potential …