Preclinical evaluation of antisense bcl‐2 as a chemosensitizer for patients with gastric carcinoma

R Kim, M Emi, K Tanabe, T Toge - … International Journal of the …, 2004 - Wiley Online Library
… , we evaluated the preclinical effect of AS bcl-2 on chemotherapy for patients with gastric …
Thus, our preclinical evaluation of AS Bcl-2 suggests that, in targeting therapy through …

Therapeutic potential of antisense Bcl‐2 as a chemosensitizer for cancer therapy

R Kim, M Emi, K Tanabe, T Toge - … International Journal of the …, 2004 - Wiley Online Library
… for patients with other malignancies. Here, the authors review the current clinical and
preclinical evaluations of AS Bcl-2 and discuss its potential to act as a chemosensitizer and to …

[HTML][HTML] Modulators of multidrug resistance: preclinical studies

JM Ford - Hematology/oncology clinics of North America, 1995 - Elsevier
… The mechanism of activity of these pharmacologic agents, termed chemosensitizers, … models
for the discovery and preclinical evaluation of new chemosensitizers, reviews those agents …

[HTML][HTML] Poly-(ADP-ribose)-polymerase inhibitors as radiosensitizers: a systematic review of pre-clinical and clinical human studies

P Lesueur, F Chevalier, JB Austry, W Waissi… - Oncotarget, 2017 - ncbi.nlm.nih.gov
… We looked for all clinical or pre-clinical studies related … chemosensitizer depending on
MGMT status stay debated [40, 56–58]even if some phase II-III clinical trials recruits only patients

Autophagy inhibition for chemosensitization and radiosensitization in cancer: do the preclinical data support this therapeutic strategy?

ML Bristol, SM Emery, P Maycotte, A Thorburn… - … of Pharmacology and …, 2013 - ASPET
… In this commentary/review, we focus on the relatively limited number of studies in the
literature where chloroquine has been tested in combination with chemotherapy or radiation in …

Phase I study of low-dose suramin as a chemosensitizer in patients with advanced non-small cell lung cancer

MA Villalona-Calero, MG Wientjes, GA Otterson… - Clinical cancer …, 2003 - AACR
… Purpose: Our preclinical studies have shown that acidic and basic fibroblastic growth factors
confer broad spectrum chemoresistance and that low concentrations (10–50 μm) of suramin…

[HTML][HTML] Proton pump inhibitor chemosensitization in human osteosarcoma: from the bench to the patients' bed

S Ferrari, F Perut, F Fagioli, A Brach Del Prever… - Journal of translational …, 2013 - Springer
Patients had to receive ESOM the two days before chemotherapy because preclinical studies
… , that is the minimal effective dose calculated on the basis of the preclinical studies [3, 4]. In …

Preclinical Evaluation of a Novel ATM Inhibitor, KU59403, In Vitro and In Vivo in p53 Functional and Dysfunctional Models of Human Cancer

MA Batey, Y Zhao, S Kyle, C Richardson, A Slade… - Molecular cancer …, 2013 - AACR
… daily resulted in the greatest chemosensitization with a 3-fold … previously observed with
chemosensitization studies (22) … only 4 hours completely abolished chemosensitization. As ATM …

Nontoxic suramin as a chemosensitizer in patients: dosing nomogram development

D Chen, SH Song, MG Wientjes, TK Yeh, L Zhao… - Pharmaceutical …, 2006 - Springer
… The present study identified and validated a dosing nomogram and schedule to deliver low
and nontoxic suramin concentrations that produce chemosensitization in preclinical models. …

Preclinical chemosensitization by PARP inhibitors

DR Shalinsky, CK Donawho, G Los… - PARP Inhibitors for Cancer …, 2015 - Springer
… Table 9.2 AbbVie data summarizing veliparib preclinical studies, monotherapy and …
produced by PARPi used as chemosensitiser in patients with advanced malignancies exposed to …