Preclinical models in HNSCC: A comprehensive review

B Méry, C Rancoule, JB Guy, S Espenel, AS Wozny… - Oral oncology, 2017 - Elsevier
… and genetic investigations in head and neck cancer and tests in a … This review focuses on
the most pertinent preclinical models of … preclinical model depending on the aim of the study. …

Preclinical models in head and neck squamous cell carcinoma

P Chaves, M Garrido, J Oliver, E Pérez-Ruiz… - British Journal of …, 2023 - nature.com
… the development of reliable preclinical models essential for the … Preclinical models of head
and neck squamous cell … In this review, we will go over the most frequently used preclinical

Preclinical evaluation of dual PI3K-mTOR inhibitors and histone deacetylase inhibitors in head and neck squamous cell carcinoma

RB Erlich, Z Kherrouche, D Rickwood… - British journal of …, 2012 - nature.com
Background: We examine the potential value of a series of clinically relevant PI3K-mTOR
inhibitors alone, or in combination with histone deacetylase inhibitors, in a model of head and …

Preclinical models of head and neck squamous cell carcinoma for a basic understanding of cancer biology and its translation into efficient therapies

I Tinhofer, D Braunholz, K Klinghammer - Cancers of the Head & Neck, 2020 - Springer
Head and neck cancer is the seventh most common cancer … Reliable preclinical models
are therefore critical to better … This review describes the mostly used preclinical models of …

A preclinical model for experimental chemotherapy of human head and neck cancer

K Sommer, SO Peters, IH Robins… - International …, 2001 - spandidos-publications.com
… We developed a mouse model in a representative human derived head and neck cancer
cell line for preclinical studies to evaluate antitumor response, tumor-free survival and host …

Preclinical In Vitro, In Vivo, and Pharmacokinetic Evaluations of FLLL12 for the Prevention and Treatment of Head and Neck Cancers

ASM Anisuzzaman, A Haque, MA Rahman… - Cancer Prevention …, 2016 - AACR
… IC 50 values against a panel of one premalignant and eight malignant head and neck
pharmacokinetic properties that induces apoptosis of head and neck cancer cell lines by inhibition …

Precision medicine in head and neck cancers: genomic and preclinical approaches

G Miserocchi, C Spadazzi, S Calpona… - Journal of Personalized …, 2022 - mdpi.com
… effects of personalised treatments, preclinical research can take … Preclinical research has
constantly implemented in vitro and … approaches aimed to improve preclinical tools to study and …

Feasibility of primary tumor culture models and preclinical prediction assays for head and neck cancer: A narrative review

AJC Dohmen, JE Swartz, MWM Van Den Brekel… - Cancers, 2015 - mdpi.com
… primary head and neck tumor … preclinical prediction assay for individual patients. With this
review, we aim to fill a gap in the understanding of primary culture models from head and neck

[HTML][HTML] Cetuximab and bevacizumab: preclinical data and phase II trial in recurrent or metastatic squamous cell carcinoma of the head and neck

A Argiris, AP Kotsakis, T Hoang, FP Worden… - Annals of oncology, 2013 - Elsevier
… We studied the combination of bevacizumab and cetuximab in head and neck (SCC1) and
lung … These results are consistent with previous preclinical observations with endostatin and …

[HTML][HTML] Targeted treatment of head and neck (pre) cancer: preclinical target identification and development of novel therapeutic applications

AM van Harten, RH Brakenhoff - Cancers, 2021 - mdpi.com
… This review focusses on the preclinical identification of … The molecular landscape of head
and neck cancer has been … the current literature on the preclinical identification of potential …