… pharmacogical inhibition reduces bone and soft tissue metastatic burden by affecting tumor growth and tumorigenic potential in prostate cancer preclinical models

GL Gravina, A Mancini, P Muzi, L Ventura… - … Prostate, 2015 - Wiley Online Library
… of normal or hyperplasic prostate, primary prostate tumors, lymph-nodes metastases, and
bone metastatic lesions. We observed that all primary prostate cancers expressed CXCR4, …

Continuous and intermittent dosing of lonafarnib potentiates the therapeutic efficacy of docetaxel on preclinical human prostate cancer models

G Liu, SA Taylor, CH Marrinan, Y Hsieh… - … journal of cancer, 2009 - Wiley Online Library
prostate cancer models including PC3, DU-145, LNCaP and 22Rv1 cells.31-35 We report
here that in the prostate cancer models … Interesting in these prostate cancer models, lonafanib …

Macrophages transduced with an adenoviral vector expressing interleukin 12 suppress tumor growth and metastasis in a preclinical metastatic prostate cancer model

T Satoh, T Saika, S Ebara, N Kusaka, TL Timme… - Cancer Research, 2003 - AACR
… To evaluate potential antimetastatic effects of AdmIL-12-transduced macrophages in this
prostate cancer model, we counted the number of macroscopic lung metastases on day 21 after …

High efficacy of docetaxel with and without androgen deprivation and estramustine in preclinical models of advanced prostate cancer

K Fizazi, CR Sikes, J Kim, J Yang… - Anticancer …, 2004 - ar.iiarjournals.org
… from one preclinical study suggested synergism between docetaxel and estramustine (6),
our results, obtained with both in vivo and in vitro models employing three prostate cancer cell …

[HTML][HTML] Preclinical assessment of the combination of PSMA-targeting radionuclide therapy with PARP inhibitors for prostate cancer treatment

EAM Ruigrok, NS Verkaik, E de Blois… - International Journal of …, 2022 - mdpi.com
cancer cell killing both in vitro and in vivo [14,15,16]. Based on these preclinical successes
with NET models, … to the preclinical studies combining TRT with PARPi in NET models, to the …

Prostate cancer chemoprevention by sulforaphane in a preclinical mouse model is associated with inhibition of fatty acid metabolism

KB Singh, SH Kim, ER Hahm, SK Pore… - …, 2018 - academic.oup.com
… In conclusion, the present study demonstrates that prostate cancer prevention by SFN in a
preclinical mouse model is associated with suppression of fatty acid synthesis and possibly …

Targeting the α receptor for platelet-derived growth factor as a primary or combination therapy in a preclinical model of prostate cancer skeletal metastasis

MR Russell, Q Liu, A Fatatis - Clinical Cancer Research, 2010 - AACR
… ) is highly expressed in primary prostate cancer and associated skeletal metastases. Here, …
used a preclinical animal model of metastasis in which PC3-ML human prostate cancer cells …

[HTML][HTML] Multimodal imaging guided preclinical trials of vascular targeting in prostate cancer

J Kalmuk, M Folaron, J Buchinger, R Pili, M Seshadri - Oncotarget, 2015 - ncbi.nlm.nih.gov
… in preclinical models to better inform future clinical trial design [31]. In this regard, non-invasive
imaging methods can enable determination of the kinetics of tumor response or regrowth …

Studies with ZD1839 in preclinical models

FM Sirotnak - Seminars in oncology, 2003 - Elsevier
… Treatment with ZD1839 alone inhibited the growth of LX-1, a lung cancer model with a
low level of EGFR expression, and PC-3, a prostate cancer model with moderate EGFR …

Preclinical models of prostate cancer.

R Royai, PH Lange, R Vessella - Seminars in oncology, 1996 - europepmc.org
… , and the human cancer is unusually hard to grow in culture or as xenografts even short-term.
The prostate cancer models that do exist are basically rodent models, human cell lines, …