[HTML][HTML] CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity

THO Nguyen, LC Rowntree, J Petersen, BY Chua… - Immunity, 2021 - cell.com
SARS-CoV-2-specific CD8 + T cells in pre-… naive precursor frequency and TCRαβ diversity
within immunodominant B7/N 105 -specific CD8 + T cells and provides insight into SARS-CoV

VarEPS: an evaluation and prewarning system of known and virtual variations of SARS-CoV-2 genomes

Q Sun, C Shu, W Shi, Y Luo, G Fan, J Nie… - Nucleic acids …, 2022 - academic.oup.com
… To our knowledge, this is the most comprehensive analysis and risk evaluation of SARS-CoV-2
genome variants. Instead of the classical risk evaluation by variation frequency, we …

Evolutionary trajectory of SARS-CoV-2 and emerging variants

J Singh, P Pandit, AG McArthur, A Banerjee… - Virology journal, 2021 - Springer
… However, the lack of robust evidence of direct SARS-CoV-2 emergence from a pangolin
CoV precursor [45], along with the reported high pathogenicity of SARSr-CoVs in infected …

Antibody levels poorly reflect on the frequency of memory B cells generated following SARS-CoV-2, seasonal influenza, or EBV infection

C Wolf, S Köppert, N Becza, S Kuerten… - Cells, 2022 - mdpi.com
… Similar to their naïve precursor cells, B mem cells are also … However, unlike their naïve
precursor cells, B mem cells are … with the Omicron variants of SARS-CoV-2 that acquired immune …

[HTML][HTML] Longitudinal isolation of potent near-germline SARS-CoV-2-neutralizing antibodies from COVID-19 patients

C Kreer, M Zehner, T Weber, MS Ercanoglu… - Cell, 2020 - cell.com
… Interestingly, potential precursor sequences were identified in naive B cell repertoires from …
SARS-CoV-2-neutralizing antibodies are readily generated from a diverse pool of precursors, …

Viral load and contact heterogeneity predict SARS-CoV-2 transmission and super-spreading events

A Goyal, DB Reeves, EF Cardozo-Ojeda, JT Schiffer… - Elife, 2021 - elifesciences.org
SARS-CoV-2 or influenza can be highly contagious for less than 1 day, congruent with peak
viral load. SARS-CoV-2 … We next plotted the frequency of exposure contacts per day for both …

SARSCoV‐2‐specific CD8+ T‐cell responses and TCR signatures in the context of a prominent HLA‐A*24:02 allomorph

LC Rowntree, J Petersen, JA Juno… - Immunology and cell …, 2021 - Wiley Online Library
… Identification of these SARS-CoV-2 CD8 + T-cell specificities allowed us to determine the
precursor frequency of SARS-CoV-2 tetramer-specific CD8 + T cells in prepandemic samples, …

The origins and molecular evolution of SARS-CoV-2 lineage B. 1.1. 7 in the UK

V Hill, L Du Plessis, TP Peacock, D Aggarwal… - Virus …, 2022 - academic.oup.com
… within which the evolutionary rate is typical of SARS-CoV-2. The Alpha epidemic continued
… was predominantly to drive the decline of the SARS-CoV-2 lineages that preceded Alpha. …

Erythroid precursors and progenitors suppress adaptive immunity and get invaded by SARS-CoV-2

S Shahbaz, L Xu, M Osman, W Sligl, J Shields, M Joyce… - Stem cell reports, 2021 - cell.com
… Despite the frequency of hypoxia, the impact of SARS-CoV-2 infection on erythropoiesis
has received limited attention. Preliminary modeling reports have suggested that SARS-CoV-2 …

[HTML][HTML] Detection, prevalence, and duration of humoral responses to SARS-CoV-2 under conditions of limited population exposure

TJ Ripperger, JL Uhrlaub, M Watanabe, R Wong… - medRxiv, 2020 - ncbi.nlm.nih.gov
… indicates frequency of negative control values in this range. … One possibility is that the avidities
of germline precursors differ … operating on SARS-CoV-2 and other coronavirus N antibody …