Predictive profiling of SARS-CoV-2 variants by deep mutational learning
… predicting their impact on ACE2 binding and antibody escape. A highly diverse landscape of
possible SARS-CoV-2 … DML may be used for predictive profiling on current and prospective …
possible SARS-CoV-2 … DML may be used for predictive profiling on current and prospective …
Integrated immunovirological profiling validates plasma SARS-CoV-2 RNA as an early predictor of COVID-19 mortality
E Brunet-Ratnasingham, SP Anand, P Gantner… - Science …, 2021 - science.org
… SARS-CoV-2 antibody responses likely play a critical role in protective immunity against
SARS-CoV-2 (26, 32), we measured plasma SARS-CoV-2… quantification using the SARS-CoV-2 …
SARS-CoV-2 (26, 32), we measured plasma SARS-CoV-2… quantification using the SARS-CoV-2 …
[HTML][HTML] A patient-centric modeling framework captures recovery from SARS-CoV-2 infection
The biology driving individual patient responses to severe acute respiratory syndrome
coronavirus 2 infection remains ill understood. Here, we developed a patient-centric framework …
coronavirus 2 infection remains ill understood. Here, we developed a patient-centric framework …
[HTML][HTML] A urinary peptidomic profile predicts outcome in SARS-CoV-2-infected patients
… This study is the first to include a specific urinary proteomic biomarker (COV50) in a model
predicting death and worsening WHO scores up to 21 days from PCR-confirmed SARS-CoV-2 …
predicting death and worsening WHO scores up to 21 days from PCR-confirmed SARS-CoV-2 …
[HTML][HTML] People critically ill with COVID-19 exhibit peripheral immune profiles predictive of mortality and reflective of SARS-CoV-2 lung viral burden
Despite extensive analyses, there remains an urgent need to delineate immune cell states
that contribute to mortality in people critically ill with COVID-19. Here, we present high-…
that contribute to mortality in people critically ill with COVID-19. Here, we present high-…
Predicting the mutational drivers of future SARS-CoV-2 variants of concern
… in SARS-CoV-2 might contribute to future variants of concern. We tested the predictive value
… and identified primary biological drivers of SARS-CoV-2 intrapandemic evolution. We found …
… and identified primary biological drivers of SARS-CoV-2 intrapandemic evolution. We found …
[HTML][HTML] SARS-CoV-2 viremia is associated with distinct proteomic pathways and predicts COVID-19 outcomes
… ED during a similar period of time with negative SARS-CoV-2 test as control. The majority of
… , SARS-CoV-2 viremia along with day 0 proteomic data yielded good predictive performance …
… , SARS-CoV-2 viremia along with day 0 proteomic data yielded good predictive performance …
[HTML][HTML] Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug …
… SARS-CoV-2 infection from naso/oropharyngeal swabs and a large-scale shotgun
metatranscriptomics platform (total-RNA-seq) for host, viral, and microbial profiling… drive …
metatranscriptomics platform (total-RNA-seq) for host, viral, and microbial profiling… drive …
[HTML][HTML] Diagnostic potential of the plasma lipidome in infectious disease: application to acute SARS-CoV-2 infection
… SARS-CoV-2-positive individuals from SARS-CoV-2-negative individuals with COVID-19-like
symptoms (specificity = 0.818). Lipid profiling and … into SARS-CoV-2, with strong predictive …
symptoms (specificity = 0.818). Lipid profiling and … into SARS-CoV-2, with strong predictive …
[HTML][HTML] Host methylation predicts SARS-CoV-2 infection and clinical outcome
IR Konigsberg, B Barnes, M Campbell… - Communications …, 2021 - nature.com
Background Since the onset of the SARS-CoV-2 pandemic, most clinical testing has focused
on RT-PCR 1 . Host epigenome manipulation post coronavirus infection 2 , 3 – 4 suggests …
on RT-PCR 1 . Host epigenome manipulation post coronavirus infection 2 , 3 – 4 suggests …
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