… Further progress towards eradication of NTDs is likely to require significantly improved
understanding of the factors, genetic and environmental, that predispose to NTDs, the embryonic …

… genetic factors predisposing to NTDs in human beings. We first present a brief review of the
normal process of neurulation, including the underlying molecular and cellular mechanisms, …

… tube defects ( NTD ) are among the most common defects affecting 1:1000 births. They are
caused by a failure of neural tube … and severity of the original defect on the embryonic axis. …

… have a genetically determined predisposition for VPA-induced NTDs… the genes that cause
risk of human neural tube defects so … Prevention of the first occurrence of neuraltube defects by …

… Neural tube defects (NTD) are one of the most common birth defects and are caused by
both environmental and genetic factors. The approach to identifying the genes predisposing to …

… were identified in the AMT gene that were absent from controls. … for GCS activity in neural
tube closure, we generated mice … -of-function mutations in GCS genes predispose to NTDs in …

Neural tube defects (NTDs), including anencephaly and spina bifida, are multifactorial diseases
that occur with an incidence of 1 in 300 births in the United Kingdom 1. Mouse models …

… candidate genes in groups of well-genotyped individuals to detect possible gene–gene …
testing of candidates genes in groups of NTDs with specific defects of folate metabolism, or …

… with the number of neural tube defect pregnancies, the levels … to offspring with neural tube
defects and depressed red cell … factor predisposing to the occurrence of neural tube defects …

… and termed neural tube defects (NTD). Failure of closure of the neural tube during
development … Future studies must address issues of gene-gene, gene-nutrient and gene–environment …