Prenatal stress affects placental cytokines and neurotrophins, commensal microbes, and anxiety-like behavior in adult female offspring

TL Gur, L Shay, AV Palkar, S Fisher, VA Varaljay… - Brain, behavior, and …, 2017 - Elsevier
… Our finding that prenatal stress affects both maternal and offspring … maternal stress influences
a host of processes, including inflammation, HPA-axis, and epigenetic regulation. Stress

Prenatal stress disrupts social behavior, cortical neurobiology and commensal microbes in adult male offspring

TL Gur, AV Palkar, T Rajasekera, J Allen… - Behavioural brain …, 2019 - Elsevier
… a prenatal stressor in pregnant mice to examine novel relationships between prenatal stress
… Here, we show that males exposed to prenatal stress had a significant reduction in social …

Unique maternal immune and functional microbial profiles during prenatal stress

AM Antonson, MV Evans, JD Galley, HJ Chen… - Scientific reports, 2020 - nature.com
Prenatal stress-induced fetal neuroinflammation is … microbial metagenome profiles of
stressed gestating mice that may trigger detrimental inflammatory signaling at the maternalfetal

[HTML][HTML] Discrete role for maternal stress and gut microbes in shaping maternal and offspring immunity

HJ Chen, A Bischoff, JD Galley, L Peck, MT Bailey… - … of stress, 2022 - Elsevier
… the interaction between maternal commensal microbes and prenatal stress in impacting …
show that prenatal stress and maternal microbes have discrete roles in regulating the maternal

A review of the impact of maternal prenatal stress on offspring microbiota and metabolites

V Yeramilli, R Cheddadi, J Shah, K Brawner, C Martin - Metabolites, 2023 - mdpi.com
… The maternal–infant microbial relationship has been relatively well-studied. However, little …
in shaping the offspring microbial communities. Commensal bacteria play a significant role in …

Prenatal stress-induced disruptions in microbial and host tryptophan metabolism and transport

JD Galley, HJ Chen, AM Antonson, TL Gur - Behavioural brain research, 2021 - Elsevier
prenatal stress (PNS) alters placental Trp and serotonin, and reduces Trp-metabolizing
members of the maternal … and transport in both the maternal and fetal compartments, and that …

[HTML][HTML] Prenatal stress leads to deficits in brain development, mood related behaviors and gut microbiota in offspring

Z Zhang, N Li, R Chen, T Lee, Y Gao, Z Yuan, Y Nie… - … of stress, 2021 - Elsevier
… To further evaluate microbial structural alteration induced by prenatal stress, we
performed … To identify overall profiles of microbial community structure, we performed beta-diversity …

Prenatal stress causes intrauterine inflammation and serotonergic dysfunction, and long-term behavioral deficits through microbe-and CCL2-dependent mechanisms

HJ Chen, AM Antonson, TA Rajasekera… - Translational …, 2020 - nature.com
… Indeed, exposure to commensal microbes is necessary for education and priming of
immune cells, and GF mice have been shown to have deficits in function of both the innate and …

Prenatal stress increases IgA coating of offspring microbiota and exacerbates necrotizing enterocolitis-like injury in a sex-dependent manner

KM Brawner, VA Yeramilli, BA Kennedy… - Brain, behavior, and …, 2020 - Elsevier
stress during pregnancy. Here we show that while prenatal stress lowers fecal IgA levels in
pregnant … coating of commensal microbes varied between offspring with stressed and non-…

[HTML][HTML] A novel role for maternal stress and microbial transmission in early life programming and neurodevelopment

E Jašarević, AB Rodgers, TL Bale - Neurobiology of stress, 2015 - Elsevier
Commensal bacteria in the mammalian gut actively ferment soluble dietary carbohydrates
… In addition to their direct role in fermentation, commensal gut microbiota express many …