We have shown that the cellular contractile dysfunction characteristic of pressure-overload
cardiac hypertrophy results not from an abnormality intrinsic to the myofilament portion of the …

… The most important finding of this study is that abolition of the hypertrophic response to
systolic pressure overload does not result in LV decompensation. This finding is supported by 6 …

… in the late phase of hypertrophic growth and associated … in the chronic pressure-overload
hypertrophy model remains … cardiac hypertrophy induced by chronic pressure overload, …

… α 2 , are critical factors in pressure overload-induced cardiac hypertrophy. This complements
reports linking elevated plasma EO to hypertension, cardiac hypertrophy, and failure in …

… [55-571 the response of the heart to sustained pressure overload in an animal model by …
the isolated heart in cardiac hypertrophy produced by pressure and volume overloading are in …

… Pressure overload and volume overload induce different phenotypic and molecular adaptations
in cardiac hypertrophy… this study predominate in pressure but not volume overload. The …

… Although numerous insights have emerged in elucidating the molecular pathogenesis of
cardiac hypertrophy, 3,36 our understanding of mechanisms underlying the myriad facets of …

… of pressure overload–induced cardiac hypertrophy, chronic pressure overload was produced
… Chronic pressure overload induced cardiac hypertrophy in KO mice as well as in WT mice, …

… When volume overload is predominant, eccentric remodeling of ventricle occurs, whereas
when pressure overload is predominant, the ventricle develops a typical concentric pattern. It …

… CHRONIC pressure overload to the cardiac ventricle is compensated at least partially by
mural hypertrophy of the ventricle. As an adaptation process, however, ventricular hypertrophy …