Update on Alzheimer's disease therapy and prevention strategies

WV Graham, A Bonito-Oliva… - Annual review of …, 2017 - annualreviews.org
Alzheimer's disease (AD) is the primary cause of age-related dementia. Effective strategies to
prevent … Significant investments in therapeutic drug discovery programs over the past two …

Therapies for prevention and treatment of Alzheimer's disease

J Mendiola-Precoma, LC Berumen… - BioMed research …, 2016 - Wiley Online Library
… The therapeutic options have focused on ameliorating the … not significantly reversed the
disease, so prevention is a better … prevention is our best strategy for AD, with efforts to prevent

[HTML][HTML] Alzheimer's disease prevention: from risk factors to early intervention

M Crous-Bou, C Minguillón, N Gramunt… - Alzheimer's research & …, 2017 - Springer
prevention, from primary prevention strategies based on identifying risk factors and risk
reduction, to secondary prevention … public–private partnerships for disease prevention that aim to …

Prevention of Alzheimer's disease: lessons learned and applied

JE Galvin - Journal of the American Geriatrics Society, 2017 - Wiley Online Library
… Although a well-balanced, healthy lifestyle may be the cornerstone of disease prevention
and … , a prevention initiative needs to be multimodal and tailored to address individual risks. …

Physical activity and Alzheimer's disease: from prevention to therapeutic perspectives

Y Rolland, GA van Kan, B Vellas - Journal of the American Medical …, 2008 - Elsevier
… the current literature on Alzheimer's disease and the effect of … Defining the optimal preventive
and therapeutic strategies in … In the future, the prevention of Alzheimer's disease may be …

Oxidative stress in Alzheimer's disease: implications for prevention and therapy

C Behl - Alzheimer's Disease: Cellular and Molecular Aspects of …, 2005 - Springer
… In Alzheimer's Disease amyloid-p protein on its way to brain … be effective in preventing
Alzheimer's Disease. Nevertheless, … and progression of Alzheimer's Disease as well as of other …

[HTML][HTML] Advances in the prevention of Alzheimer's Disease

S Sindi, F Mangialasche, M Kivipelto - F1000prime reports, 2015 - ncbi.nlm.nih.gov
… Characteristics of selected RCTs for prevention of cognitive impairment, dementia and
Alzheimer's disease based on multidomain interventions (Table adapted from [5]) …

Anti-amyloidogenic therapies: strategies for prevention and treatment of Alzheimer's disease

T Hamaguchi, K Ono, M Yamada - Cellular and Molecular Life Sciences …, 2006 - Springer
Deposition of amyloid β-protein (Aβ) in the brain is an early and invariant neuropathological
feature of Alzheimer’s disease (AD). The current search for anti-AD drugs is mainly focused …

Antioxidant neuroprotection in Alzheimer's disease as preventive and therapeutic approach

C Behl, B Moosmann - Free Radical Biology and Medicine, 2002 - Elsevier
… ) have been intensively studied in Alzheimer’s disease (AD). … Antioxidants that prevent the
detrimental consequences of … are currently considered for AD prevention and therapy. Here, …

Toward the treatment and prevention of Alzheimer's disease: rational strategies and recent progress

S Gandy, ST DeKosky - Annual review of medicine, 2013 - annualreviews.org
… decade and beyond have made Alzheimer's disease (AD) a major health care threat. As
discussed below, research is now focusing on prevention as well as symptomatic treatment. In …