… COX-2 inhibitors have been reported to effectively prevent … role of COX-2 as a target for
the prevention and treatment of … Interest in cyclooxygenase (COX) as a therapeutic target for …

… selective inhibitors of COX-2 are effective in the prevention and treatment of cancer. …
that cyclooxygenase 2 (COX-2) is a bona fide pharmacological target for anti-cancer therapy. …

… Cyclooxygenase-2 (COX-2) is being intensively evaluated as a pharmacologic target for
both the prevention and treatment of cancer. Aberrant COX-2 expression was initially described …

… Eberhart CE, Coffey RJ, Radhika A, Giardiello FM, Ferrenbach S & DuBois RN 1994 Up-regulation
of cyclooxygenase 2 gene expression in human colorectal adenomas and …

… and therapy … of cyclooxygenase-2 inhibitors in adjuvant chemotherapy. Therefore, our ability
to efficiently target the oncogenic effects of cyclooxygenase-2 for therapeutic and preventive …

… cyclooxygenase 2 (COX 2), an inducible form of the enzyme, is a potential pharmacological
target to prevent … Key data implicating a causal relation between increased activity of COX 2 …

… Thus, our data indicate that COX-2-inhibitory drugs have therapeutic effects in addition to
acting via preventive mechanisms. In this regard, stereomicroscopic examination of the …

… , and cardiovascular diseasesand now are under consideration for the prevention of colon
cancer and AD.COX-2 selective agents appear to be an improvement over conventional …

… in all the different subgroups in all three COX-2 inhibitor studies. These data suggest that 1
year of therapy might be sufficient to prevent polyp recurrence. Given that it is quite possible …

A plentiful literature has linked colorectal cancer (CRC) to inflammation and prostaglandin-endoperoxide
synthase (PTGS)2 expression. Accordingly, several nonsteroidal …