… The main purpose of this randomized phase II trial was to compare clinical feasibility—defined
as the absence of dose-limiting toxic effects (DLTs), premature treatment withdrawal or …

… However, dose-intensified chemotherapy is associated with a … to chemotherapy [15, 16].
Erythropoiesis-stimulating agents are known to prevent and reduce the grade of chemotherapy-…

… taken from an open-label, phase 3, multicenter randomized controlled trial (ClinicalTrials.gov …
Patients who received previous chemotherapy or RT or who had other malignant tumors …

… arm (38.0% by intention-to-treat or 54.3% by per-protocol analysis) is encouraging compared
with previous data on the combination of 5-fluorouracil (5-FU) and cisplatin, showing CR …

… weeks; no previous chemotherapy for advanced disease and no previous targeted molecular
therapy… Previous radiation therapy was permitted if limited to <25% of the bone marrow and …

… Previous treatment with radiotherapy and/or systemic chemotherapy was a criterion of
exclusion. Patient age had to be less than 70 years and performance status had to be greater than …

… Our previous studies showed the high efficacy of gefitinib treatment in Taiwanese patients with
adenocarcinoma who failed previous chemotherapy.20… Randomized phase II clinical trials …

… given alone in an open-label, randomized phase III trial in elderly patients with advanced …
our previous data with vinorelbine, showing that administration of vinorelbine chemotherapy …

… However, when tested in our previous feasibility study, the sequential induction regimen …
the combination regimen, as compared with the previous trial onto which similar patients were …

… Further eligibility criteria were similar to our previous phase 2 trial (Table 1).11 After written …
different chemotherapeutic agents. The design of the current trial was similar to other phase 3 …