Risks of untreated and treated isolated systolic hypertension in the elderly: meta-analysis of outcome trials

JA Staessen, J Gasowski, JG Wang, L Thijs… - The Lancet, 2000 - thelancet.com
… did not provide specific estimates of the risks in treated and untreated older patients with …
In untreated control patients we first evaluated the risk conferred by systolic and diastolic …

Thalidomide for previously untreated elderly patients with multiple myeloma: meta-analysis of 1685 individual patient data from 6 randomized clinical trials

, … Network, Turkish Myeloma Study Group … - Blood, The Journal …, 2011 - ashpublications.org
… We conclude that thalidomide added to MP improves OS and PFS in previously untreated
elderly patients with multiple myeloma, extending the median survival time by on average 20%…

MP versus MPT for previously untreated elderly patients with multiple myeloma: A meta-analysis of 1,682 individual patient data from six randomized clinical trials.

A Waage, AP Palumbo, P Fayers, M Beksac… - Journal of Clinical …, 2010 - ascopubs.org
8130 Background: Randomized clinical trials including previously untreated patients were
initiated in Italy, France (2), Netherlands/Belgium, and Nordic countries in 2000-2002 and in …

A network meta-analysis of therapies for previously untreated chronic lymphocytic leukemia

MM Cheng, B Goulart, DL Veenstra, DK Blough… - Cancer treatment …, 2012 - Elsevier
… We excluded a trial that compared fludarabine with chlorambucil 15 because the patient
population was older, and older patients have higher competing mortality risks compared with …

Systematic review with metaanalysis: inflammatory bowel disease in the elderly

JP Gisbert, M Chaparro - Alimentary pharmacology & …, 2014 - Wiley Online Library
… important to study and optimise health care delivery to the elderly.8 Elderly patients with IBD
… The World Health Organization defines elderly persons as those aged ≥65 years; however, …

Treatment of hypertension in patients 80 years and older: the lower the better? A meta-analysis of randomized controlled trials

T Bejan-Angoulvant, M Saadatian-Elahi… - Journal of …, 2010 - journals.lww.com
… In conclusion, particular attention should be given to hypertensive elderly patients who
constitute a large, growing and vulnerable population. Treating hypertension in very old …

[HTML][HTML] Efficacy outcomes in the treatment of older or medically unfit patients with acute myeloid leukaemia: a systematic review and meta-analysis

A Stone, T Zukerman, L Flaishon, RB Yakar… - Leukemia Research, 2019 - Elsevier
Older patients and those with comorbidities and poor performance status at diagnosis are
less tolerant to this intensive therapy, and they have increased treatment-related morbidity and …

Duration of untreated illness and outcomes in unipolar depression: a systematic review and meta-analysis

L Ghio, S Gotelli, M Marcenaro, M Amore… - Journal of affective …, 2014 - Elsevier
… The present study provides a systematic review and meta-analysis of all available empirical
investigations on the relationship between the duration of untreated depression and clinical …

Meta-analysis of molecular targeted agents in the treatment of elderly patients with metastatic colorectal cancer: Does the age matter?

CJ Zhao, SL Li, Q Liu - Journal of Cancer Research and …, 2018 - journals.lww.com
… In conclusion, this is the first-meta-analysis to specifically assess the role of MTAs in the
treatment of elderly patients with mCRC. Our study confirms that the addition of MTAs to the …

[HTML][HTML] … bevacizumab combined with fluoropyrimidine monotherapy for unfit or older patients with metastatic colorectal cancer: a systematic review and meta-analysis

C Pinto, L Antonuzzo, L Porcu, G Aprile… - Clinical Colorectal …, 2017 - Elsevier
… phase II trials, and 1 prospective cohort study in the present meta-analysis (n = 782). The
monochemotherapy administered was capecitabine in 531 patients (67.9%) and 5-fluorouracil …