… 2 (12%) of 17 primary glioblastomas but none in secondary glioblastomas (Table 1). EGFR
… in 5 (29%) of 17 primary glioblastomas but in none of the secondary glioblastomas (Table 1). …

… , but is not typically involved in the development of primary glioblastomas. The low frequency
of LOH 19q in primary glioblastomas observed in this study (6%) may reflect the stringent …

… been specifically observed in primary glioblastoma, whereas 10p LOH … loss of TIMP-3
expression are observed more frequently in secondary glioblastoma than in primary glioblastoma […

… According to the classical model of the molecular GB pathway, primary glioblastoma is … in
primary GB [26, 27]. To ascertain that the tumors studied were primary glioblastomas we used …

… Primary glioblastomas occur in older patients and are … secondary glioblastomas occur in
younger patients and contain p53 mutations as a genetic hallmark.4, 5 Loss of heterozygosity (…

… In 1996, we reported evidence that primary and secondary glioblastomas carry distinct …
in primary glioblastomas but occurred with a high incidence in secondary glioblastomas; EGF …

… They affect mainly the elderly and are genetically characterized by loss of heterozygosity
10q (70% of cases), EGFR amplification (36%), p16 INK4a deletion (31%), and PTEN …

… Here we analyze 70 primary human gliomas of all types and grades and report somatic
deletion mapping as well as single nucleotide polymorphism analysis together with quantitative …

… from 24 glioblastoma tumors are in fact aneuploid. Some putative whole-chromosome losses
… -chromosomal losses are in fact relative losses against a triploid or tetraploid background. …

… LOH analysis of 17 primary GBM patient samples using KLF6… concomitant decreases in
all primary GBM tumors (n = 11) by … are common findings in primary GBM tumors, and these …