Statins in the primary prevention of cardiovascular disease

Ž Reiner - Nature Reviews Cardiology, 2013 - nature.com
… Several meta-analyses have been published on the effects of statins in primary prevention
of CVD. Only meta-analyses published since 2006 with access to contemporary trial data are …

Statins for the primary prevention of cardiovascular disease

S Ebrahim, FC Taylor, P Brindle - Bmj, 2014 - bmj.com
… of statins for primary prevention of … effects are more common with aggressive lowering of
cholesterol levels by means of potent statins such as rosuvastatin or higher doses of statins (…

Efficacy of statins for primary prevention in people at low cardiovascular risk: a meta-analysis

M Tonelli, A Lloyd, F Clement, J Conly, D Husereau… - CMAj, 2011 - Can Med Assoc
… We categorized statins according to their pharmacologic effect on lowering cholesterol as
either low potency (fluvastatin, lovastatin, pravastatin and simvastatin) or high potency (…

Primary prevention of cardiovascular diseases with statin therapy: a meta-analysis of randomized controlled trials

P Thavendiranathan, A Bagai… - Archives of Internal …, 2006 - jamanetwork.com
… study-level patient characteristics and the benefit of statins for primary prevention. In conclusion,
while statins did not have significant effect on CHD mortality or all-cause mortality, these …

Starting primary prevention earlier with statins

JG Robinson - The American journal of cardiology, 2014 - Elsevier
effects, the guideline recommends statin therapy for primary … limited primary prevention
recommendations for statins in … initiation of statin therapy for primary prevention in lower-risk …

Statins for the primary prevention of coronary heart disease

M Li, X Wang, X Li, H Chen, Y Hu… - BioMed Research …, 2019 - Wiley Online Library
… shown that statins have large secondary prevention effects in patients … that intensive statin
therapy has an excellent effect on … However, it is unclear whether statins have similar benefits …

Statins for the primary prevention of cardiovascular disease: an overview of systematic reviews

P Byrne, J Cullinan, A Smith, SM Smith - BMJ open, 2019 - bmjopen.bmj.com
statin versus control as well as five of more versus less statin. … less statin did not include any
primary prevention participants… effect by stopping the statin therapy, whereas ‘harmful effects

Effects of statins for primary prevention in the elderly: recent evidence

K Kim, SH Lee - Journal of Lipid and Atherosclerosis, 2020 - synapse.koreamed.org
primary cardiovascular prevention in this population.We recently analyzed the effect of statins
on clinical outcomes for primary prevention in … the effects of statins for primary prevention in …

Statins and cardiovascular primary prevention in CKD: a meta-analysis

RW Major, CK Cheung, LJ Gray… - Clinical Journal of the …, 2015 - journals.lww.com
… the use of statins in CKD for primary prevention of cardiovascular … guidance for the use of
statins in all patients with CKD. … of statins to either lipid-lowering properties or pleiotropic effects

Statins and all-cause mortality in high-risk primary prevention: a meta-analysis of 11 randomized controlled trials involving 65 229 participants

KK Ray, SRK Seshasai, S Erqou, P Sever… - Archives of internal …, 2010 - jamanetwork.com
… et al 5 who stated that “in some subgroups statins cause serious unrecognized harm, which
negates the beneficial effects if the benefit is small—ie, most primary prevention settings.” …