… on our current understanding of TTR amyloid fibril formation. Our present knowledge of this
… associated amyloid diseases are better understood than any other human amyloid disease […

… Amyloid fibrils formed from prion protein (PrP) are associated with prion diseases. In this …
PrP amyloid fibrils in vitro. We first examined the effects of ultrasonic power on the induction of …

… prion disease can be generated de novo in wild type animals by recombinant PrP (rPrP)
amyloid fibrils… When induced by rPrP fibrils, a long silent stage that involved two serial passages …

… in human PrP, leading to genetic prion diseases with distinct clinical syndromes. … amyloid
fibril formed by full-length human PrP with E196K mutation, a genetic Creutzfeldt-Jakob disease…

… PrP and the (-amyloid protein of Mzhelmer disease share a … ) forms amyloid fibrils. The
existence of a kinetic barrier to … The brains ofGSS patients contain amyloid fibrils composed ofan …

… β-sheet fibrils is the most important event in amyloid diseases. The … amyloid diseases, AD,
prion diseases and mouse senile amyloidosis in which Aβ, PrP Sc and AApoAII amyloid fibrils …

… cofactors in prion infectivity as well as the structural basis of prion formation. In … amyloid
fibrils generated from bacterially expressed prion protein fragment 23-144 cause prion disease …

… develop neurodegeneration characteristic of prion disease after long … PrP fibrils should
contribute to our understanding of prion disease. Here we assemble homogeneous amyloid fibrils …

… these amyloid fibrils of Mo rPrP 89−230 induced prion disease … the amyloid fibrils, however,
suggests that the fibrils generated … in production of infections prions? One may speculate that …

… Our findings support the hypothesis that development of prion disease is controlled by a
fine dynamic balance between self-propagation and clearance/deactivation of PrP Sc . …