… Excluding this mutation from our analyses of clinical features of GRN+ FTLD-TDP did not
affect our finding that patients with GRN+ FTLD-TDP are younger at onset of the disease vs …

… Marked variation in the disease course and clinical features are common, not only between
families with different mutations, but also within individual families. This degree of clinical …

… whether the loss of progranulin leads to the accumulation of TARDBP. In this Rapid Review,
we focus on the clinical and pathological phenotypes associated with mutations in GRN, …

… in GRN on chromosome 17 have been associated clinically with an FTD syndrome and
FTLD-U pathologic characteristics. There are some clinical features that seem to distinguish …

… , presumably secondary to PGRN mutations, and prior to overt … of clinical and pathological
phenotypes in PGRN mutation … PGRN mutation, even when associated with clinical features …

… clinical syndromes, all attributed to frontotemporal lobar degeneration. We describe 2 patients
with progranulin gene mutations … of 2 unrelated patients with progranulin mutations at the …

… Therefore, we suggest that TDP-43 immunohistochemistry be considered in cases with
clinical features of FTD, but pathological diagnosis other than FTLD. In two cases with striking …

… in detail the clinical data of the patients carrying the 3 GRN missense mutations and the …
In conclusion, the clinical and functional findings strongly suggest that GRN C105Y is likely …

… mutations in tau (MAPT) and progranulin (PGRN) genes. All FTLD patients had undergone
longitudinal neuropsychological and clinical … Six different PGRN mutations were found in 13 (6…

… Mutations in the progranulin (GRN) gene have recently been … We performed a clinical,
neuropathological and molecular … mutation (c.709-2, A>G) in two families with notable clinical …