… Nonetheless, integration of complementary functional information from both rare and
from common diseases promises to greatly increase our understanding of human biology. …

… Nonetheless, integration of complementary functional information from both rare and from
common diseases promises to greatly increase our understanding of human biology. We …

… Parkinson's disease (PD), a complex disorder of the central nervous system. PD is the second
most common neurodegenerative disease in the United States, after Alzheimer's disease. …

… (allele frequency > 1%), leading to the hypothesis that our individual genetic risk for common
diseases derives mostly from common variants, as opposed to the rare variants or de novo …

… Yet progress has accelerated since the 2012 London … with new commitments to overcome
these diseases. Today, we are … in the less common form of the disease (Tb rhodesiense). …

… More recently, empowered by rapid progress in cell and molecular biology based … from our
most common diseases. This essay will examine the characteristics of those diseases from a …

… Recent developments in genomics research have boosted progress in the discovery of … in
the pathogeneses of common diseases ( 1 ). One of the major promises is that these advances …

… most common chronic diseases (or disease events). Evidence-based HRAs coupled to
predictive models will facilitate assessment of a patient's disease … coronary heart disease model, …

… Dicerna treats both rare and common diseases with its 14 therapeutics (Figure 11).
Sirnaomics, headquartered in Maryland, USA, has developed over 19 therapies for human …

… of major basic science promises to clinical applications has … etiological complexity of most
common diseases; while clinical … focus on diseases with global impact, if true progress is to be …