The diagnosis of primary progressive multiple sclerosis

JS Wolinsky, PROMiSe Study Group - Journal of the neurological …, 2003 - Elsevier
Primary progressive multiple sclerosis (PPMS) is a rather unique form of the more common
relapsing inflammatory demyelinative disease. The absence of attacks that typify relapsing …

The pathology of primary progressive multiple sclerosis

W Brück, C Lucchinetti… - Multiple Sclerosis …, 2002 - journals.sagepub.com
The present review will focus on the current knowledge of the pathology of primary progressive
multiple sclerosis lesions. Multiple sclerosis (MS) is an inflammatory demyelinating …

Mechanism-based criteria to improve therapeutic outcomes in progressive multiple sclerosis

HYF Yong, VW Yong - Nature Reviews Neurology, 2022 - nature.com
… In contrast to the multiple disease-modifying therapies that are available for relapsing–remitting
multiple sclerosis (MS), the therapeutic options for progressive MS (PMS) are limited. …

Natural history of secondary-progressive multiple sclerosis

H Tremlett, Y Zhao… - Multiple Sclerosis Journal, 2008 - journals.sagepub.com
… and risk factors for progression to and from secondary-progressive multiple sclerosis (SPMS). …
The clinical features and natural history of primary progressive multiple sclerosis . Brain …

Setting a research agenda for progressive multiple sclerosis: the International Collaborative on Progressive MS

RJ Fox, A Thompson, D Baker… - Multiple Sclerosis …, 2012 - journals.sagepub.com
… for progressive forms of multiple sclerosis. … progressive MS will require an integrated,
multi-disciplinary approach to enable effective translation of research into therapies for progressive

Progressive multiple sclerosis

D Ontaneda - CONTINUUM: Lifelong Learning in Neurology, 2019 - journals.lww.com
… The 2017 McDonald diagnostic criteria for multiple sclerosis include specific criteria for
primary progressive multiple sclerosis, including 1 year of disability progression (retrospectively …

Defining active progressive multiple sclerosis

F Sellebjerg, L Börnsen, C Ammitzbøll… - Multiple Sclerosis …, 2017 - journals.sagepub.com
… with progressive multiple sclerosis as assessed by Spearman rank correlation analysis. …
damage in patients with progressive forms of multiple sclerosis. J Neurol 2014; 261: 2338–2343. …

Diagnosis and management of progressive multiple sclerosis

G Macaron, D Ontaneda - Biomedicines, 2019 - mdpi.com
Multiple sclerosis is a chronic autoimmune disease of the central nervous system that results
in varying degrees of disability. Progressive multiple sclerosis… (primary progressive) or after …

Cladribine in treatment of chronic progressive multiple sclerosis

JC Sipe, JS Romine, JA Koziol, R McMillan, E Beutler… - The Lancet, 1994 - Elsevier
Chronic progressive multiple sclerosis (MS) is a severely disabling demyelinating disease in
which autoimmune processes seem to have a major role. The nucleoside drug cladribine is …

Ocrelizumab versus placebo in primary progressive multiple sclerosis

X Montalban, SL Hauser, L Kappos… - New england journal …, 2017 - Mass Medical Soc
… In this phase 3 trial, we randomly assigned 732 patients with primary progressive multiple
sclerosis in a 2:1 ratio to receive intravenous ocrelizumab (600 mg) or placebo every 24 …