Therapeutic advances and challenges in the treatment of progressive multiple sclerosis

LE Baldassari, RJ Fox - Drugs, 2018 - Springer
… , collectively referred to as progressive MS, has proven quite … of multiple sclerosis in general,
specifically that of progressive … differences between relapsing and progressive forms of MS, …

Natural history of multiple sclerosis: a unifying concept

C Confavreux, S Vukusic - Brain, 2006 - academic.oup.com
progressive multiple sclerosis were pooled in a group of 282 patients with a progressive initial
course of multiple sclerosis … patients with secondary progressive multiple sclerosis (Table 3…

Demyelination versus remyelination in progressive multiple sclerosis

S Bramow, JM Frischer, H Lassmann… - Brain, 2010 - academic.oup.com
… efficacy of immunomodulatory treatment for progressive multiple sclerosis. The best correlates
of … with clinically well-characterized progressive multiple sclerosis, we report higher brain …

Primary and secondary progressive multiple sclerosis

S Vukusic, C Confavreux - Journal of the neurological sciences, 2003 - Elsevier
… The progressive phase of multiple sclerosis (MS) is the one … remains about the place of
primary progressive MS (PP-MS): … different MS subtypes with a progressive phase. We discuss …

Course and prognosis of chronic progressive multiple sclerosis: results of an epidemiological study

JM Minderhoud, JH Van der Hoeven… - Acta neurologica …, 1988 - Wiley Online Library
… When we summarize these results it seems likely that the course of multiple sclerosis is
characterized by a first phase with relapsing and remitting signs and symptoms and a later phase …

Primary progressive multiple sclerosis: a 5‐year clinical and MR study

GT Ingle, VL Stevenson, DH Miller, AJ Thompson - Brain, 2003 - academic.oup.com
Longitudinal imaging studies of primary progressive multiple sclerosis (PPMS) have shown
significant changes in MR measures over 1 to 2 years. Correlation with clinical change over …

Secondary progressive multiple sclerosis: definition and measurement

D Plantone, F De Angelis, A Doshi, J Chataway - CNS drugs, 2016 - Springer
progressive multiple sclerosis (SPMS) is diagnosed retrospectively and involves a clinical
course characterized by a progressive … underlying neurodegeneration in multiple sclerosis (MS…

Association of initial disease-modifying therapy with later conversion to secondary progressive multiple sclerosis

JWL Brown, A Coles, D Horakova, E Havrdova… - Jama, 2019 - jamanetwork.com
… Beta-interferon exposure and onset of secondary progressive multiple sclerosis.  … sustained
disability accrual termed secondary progressive multiple sclerosis. This phase is responsible …

Mitoxantrone in progressive multiple sclerosis: a placebo-controlled, double-blind, randomised, multicentre trial

HP Hartung, R Gonsette, N Konig, H Kwiecinski… - The Lancet, 2002 - thelancet.com
… Treatment options for patients with secondary progressive multiple sclerosis are few.
Encouraging results in open-label studies prompted this randomised trial of mitoxantrone in such …

Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study

L Kappos, A Bar-Or, BAC Cree, RJ Fox, G Giovannoni… - The Lancet, 2018 - thelancet.com
Background No treatment has consistently shown efficacy in slowing disability progression
in patients with secondary progressive multiple sclerosis (SPMS). We assessed the effect of …