Progressive neurodegeneration across chronic stages of severe traumatic brain injury
… traumatic brain injury (TBI) typically focuses on the immediate, postimpact primary injuries
… have revealed progressive losses to brain volume (including whole brain and substructures…
… have revealed progressive losses to brain volume (including whole brain and substructures…
Progressive inflammation‐mediated neurodegeneration after traumatic brain or spinal cord injury
… Traumatic brain injury (TBI) has been linked to dementia and chronic … can cause
progressive neurodegeneration that may be treatable even weeks after traumatic injury. …
progressive neurodegeneration that may be treatable even weeks after traumatic injury. …
Traumatic brain injury and risk of neurodegenerative disorder
… neurodegeneration. We review the evidence for TBI as a risk factor for neurodegenerative
… Further, we describe the dynamic interactions between acute response to injury and chronic …
… Further, we describe the dynamic interactions between acute response to injury and chronic …
Understanding neurodegeneration after traumatic brain injury: from mechanisms to clinical trials in dementia
NSN Graham, DJ Sharp - Journal of Neurology, Neurosurgery & …, 2019 - jnnp.bmj.com
… which arise from progressive neurodegenerative pathologies. Disentangling the direct effects
of TBI from those of a slowly progressive neurodegenerative process using clinical history …
of TBI from those of a slowly progressive neurodegenerative process using clinical history …
Progressive neurodegeneration after experimental brain trauma: association with chronic microglial activation
… Recent clinical studies indicate that traumatic brain injury (TBI) produces chronic and
progressive neurodegenerative changes leading to late neurologic dysfunction, but little is known …
progressive neurodegenerative changes leading to late neurologic dysfunction, but little is known …
Progressive neurodegeneration following spinal cord injury: implications for clinical trials
G Ziegler, P Grabher, A Thompson, D Altmann… - Neurology, 2018 - AAN Enterprises
… Our findings illustrate the progressive and enduring neurodegenerative and plastic … a
temporally structured neurodegenerative process that encompasses the spinal cord and brain. The …
temporally structured neurodegenerative process that encompasses the spinal cord and brain. The …
Axonal marker neurofilament light predicts long-term outcomes and progressive neurodegeneration after traumatic brain injury
Axonal injury is a key determinant of long-term outcomes after traumatic brain injury (TBI) but
has been difficult to measure clinically. Fluid biomarker assays can now sensitively quantify …
has been difficult to measure clinically. Fluid biomarker assays can now sensitively quantify …
Mild traumatic brain injury: a risk factor for neurodegeneration
… Recently, it has become clear that head trauma can lead to a progressive neurodegeneration
known as chronic traumatic encephalopathy. Although the medical literature also …
known as chronic traumatic encephalopathy. Although the medical literature also …
Pathological correlations between traumatic brain injury and chronic neurodegenerative diseases
… Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative syndrome
associated with repeated blunt force impacts to the head with transfer of acceleration and …
associated with repeated blunt force impacts to the head with transfer of acceleration and …
[HTML][HTML] Chronic neurodegeneration after traumatic brain injury: Alzheimer disease, chronic traumatic encephalopathy, or persistent neuroinflammation?
… TBI consistent with progressive neurodegeneration over periods ranging … of progressive
neurodegeneration have been demonstrated after moderate and even single mild head injuries […
neurodegeneration have been demonstrated after moderate and even single mild head injuries […
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