Progressive neurodegeneration across chronic stages of severe traumatic brain injury

Z Belchev, A Gilboa, M Binns, B Colella… - The Journal of Head …, 2022 - journals.lww.com
… traumatic brain injury (TBI) typically focuses on the immediate, postimpact primary injuries
… have revealed progressive losses to brain volume (including whole brain and substructures…

Progressive inflammation‐mediated neurodegeneration after traumatic brain or spinal cord injury

AI Faden, J Wu, BA Stoica… - British journal of …, 2016 - Wiley Online Library
… Traumatic brain injury (TBI) has been linked to dementia and chronic … can cause
progressive neurodegeneration that may be treatable even weeks after traumatic injury. …

Traumatic brain injury and risk of neurodegenerative disorder

BL Brett, RC Gardner, J Godbout, K Dams-O'Connor… - Biological …, 2022 - Elsevier
neurodegeneration. We review the evidence for TBI as a risk factor for neurodegenerative
… Further, we describe the dynamic interactions between acute response to injury and chronic …

Understanding neurodegeneration after traumatic brain injury: from mechanisms to clinical trials in dementia

NSN Graham, DJ Sharp - Journal of Neurology, Neurosurgery & …, 2019 - jnnp.bmj.com
… which arise from progressive neurodegenerative pathologies. Disentangling the direct effects
of TBI from those of a slowly progressive neurodegenerative process using clinical history …

Progressive neurodegeneration after experimental brain trauma: association with chronic microglial activation

DJ Loane, A Kumar, BA Stoica… - … of Neuropathology & …, 2014 - academic.oup.com
… Recent clinical studies indicate that traumatic brain injury (TBI) produces chronic and
progressive neurodegenerative changes leading to late neurologic dysfunction, but little is known …

Progressive neurodegeneration following spinal cord injury: implications for clinical trials

G Ziegler, P Grabher, A Thompson, D Altmann… - Neurology, 2018 - AAN Enterprises
… Our findings illustrate the progressive and enduring neurodegenerative and plastic … a
temporally structured neurodegenerative process that encompasses the spinal cord and brain. The …

Axonal marker neurofilament light predicts long-term outcomes and progressive neurodegeneration after traumatic brain injury

NSN Graham, KA Zimmerman, F Moro… - Science translational …, 2021 - science.org
Axonal injury is a key determinant of long-term outcomes after traumatic brain injury (TBI) but
has been difficult to measure clinically. Fluid biomarker assays can now sensitively quantify …

Mild traumatic brain injury: a risk factor for neurodegeneration

BE Gavett, RA Stern, RC Cantu, CJ Nowinski… - Alzheimer's research & …, 2010 - Springer
… Recently, it has become clear that head trauma can lead to a progressive neurodegeneration
known as chronic traumatic encephalopathy. Although the medical literature also …

Pathological correlations between traumatic brain injury and chronic neurodegenerative diseases

M Cruz-Haces, J Tang, G Acosta, J Fernandez… - … neurodegeneration, 2017 - Springer
… Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative syndrome
associated with repeated blunt force impacts to the head with transfer of acceleration and …

[HTML][HTML] Chronic neurodegeneration after traumatic brain injury: Alzheimer disease, chronic traumatic encephalopathy, or persistent neuroinflammation?

AI Faden, DJ Loane - Neurotherapeutics, 2015 - Elsevier
… TBI consistent with progressive neurodegeneration over periods ranging … of progressive
neurodegeneration have been demonstrated after moderate and even single mild head injuries […