Single-cell repertoire analysis demonstrates that clonal expansion is a prominent feature of the B cell response in multiple sclerosis cerebrospinal fluid
GP Owens, AM Ritchie, MP Burgoon… - The Journal of …, 2003 - journals.aai.org
… clonal expansion was a prominent feature of the IgG repertoire in three of four MS patients.
Two dominant clonal … One clonal B cell population revealed multiple L chain rearrangements, …
Two dominant clonal … One clonal B cell population revealed multiple L chain rearrangements, …
Clonal expansion in non-cancer tissues
N Kakiuchi, S Ogawa - Nature Reviews Cancer, 2021 - nature.com
… is also constrained by tissue-specific anatomical features (Figs 1 and 2). In the colorectal …
Age-related, progressive positive selection of clones in normal tissues is more prominent in the …
Age-related, progressive positive selection of clones in normal tissues is more prominent in the …
T cell clonal expansion and STAT3 mutations: a characteristic feature of acquired chronic T cell-mediated pure red cell aplasia
F Kawakami, T Kawakami, T Yamane… - International Journal of …, 2022 - Springer
… We therefore speculate that STAT3 mutations may have occurred in the clonally expanded
T cells. However, we are not sure whether or not such immuno-genetic sequential events may …
T cells. However, we are not sure whether or not such immuno-genetic sequential events may …
Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution
A Humphries, B Cereser, LJ Gay… - Proceedings of the …, 2013 - National Acad Sciences
… Correspondingly, apoptosis at the crypt base, the likely location of the stem cell compartment
(4), is a prominent feature of small adenomas [those less than 5 mm in diameter (44)], …
(4), is a prominent feature of small adenomas [those less than 5 mm in diameter (44)], …
Consequences of clonality for sexual fitness: Clonal expansion enhances fitness under spatially restricted dispersal
WE Van Drunen, M van Kleunen… - Proceedings of the …, 2015 - National Acad Sciences
… Modular growth, clonality, and hermaphroditism are widespread features of sessile … We
assess the most prominent statistical claims offered by Trump and his allies as evidence of …
assess the most prominent statistical claims offered by Trump and his allies as evidence of …
RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues
… Macroscopic clonal expansions, characterized by shared somatic mutations, are detected
in all tissues; skin, esophagus, and lung have the largest number of somatic mutations. …
in all tissues; skin, esophagus, and lung have the largest number of somatic mutations. …
Clonal expansion of CD4+ cytotoxic T lymphocytes in patients with IgG4-related disease
… Fibrosis is a prominent feature of many chronic inflammatory disorders, including rheumatoid
arthritis, systemic sclerosis, systemic lupus erythematosus, and IgG 4 -RD, among others. …
arthritis, systemic sclerosis, systemic lupus erythematosus, and IgG 4 -RD, among others. …
Clonal expansion within the CD4+ CD57+ and CD8+ CD57+ T cell subsets in chronic lymphocytic leukemia.
D Serrano, J Monteiro, SL Allen, J Kolitz… - … (Baltimore, Md.: 1950 …, 1997 - journals.aai.org
… It is of course possible that the clonally expanded CD4+CD57+ T cells we have observed
are not specific for the CLL cells and play no role in their proliferation, but rather are directed …
are not specific for the CLL cells and play no role in their proliferation, but rather are directed …
Field cancerization, clonality, and epithelial stem cells: the spread of mutated clones in epithelial sheets
SB Garcia, HS Park, M Novelli… - The Journal of …, 1999 - Wiley Online Library
… clone, there are instances where such clones expand and … The main example is the movement
of mutated clonal crypts … is a prominent feature of malignant tissues and many new clones …
of mutated clonal crypts … is a prominent feature of malignant tissues and many new clones …
Marginal-zone B cells in the human lymph node and spleen show somatic hypermutations and display clonal expansion
A Tierens, J Delabie, L Michiels… - Blood, The Journal …, 1999 - ashpublications.org
… ,13Cases of reactive lymphadenitis with a prominent proliferation of monocytoid B cells have
… including a prominent marginal zone. The patient characteristics are summarized in Table1. …
… including a prominent marginal zone. The patient characteristics are summarized in Table1. …
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