… The 21 interleukin-1 (IL-1) receptor antagonist (IL1RA), as a naturally occurring receptor
antagonist, is the first discovered and 22 can compete with IL-1 in binding to the receptor. …

… how to rejuvenate efforts to test promising cytokines, as well as to … clinical use of cytokines
and cytokine antagonists, scientists … A recombinant human IL-1 receptor antagonist, (anakinra, …

… IL‐4 receptors has shown promising early results in … cytokines, low-molecular-weight receptor
antagonists and drugs that block the signal transduction pathways activated by cytokines 6 …

… receptor antagonists and promising candidates in advanced clinical trials. Areas covered:
We will describe clinical aspects of chemokine receptor antagonists … conserved cytokines or …

… Chemokines belong to a family of chemotactic cytokines that … The promise of chemokine
receptor antagonists as potent … variety of chemokine receptor antagonists have been initiated…

… Recently, low molecular mass of IL-6 receptor antagonists presented for the first time has
been applied to inhibit gp130 homodimerization, and sequentially resulting in inhibition of …

… Alternative therapies currently being explored include phosphodiesterase 4 inhibitors,
leukotriene receptor antagonists, and inhibitors of 5- lipoxygenase and cyclooxygenase. More …

… 1), and blocking this receptor could be a promising therapeutic tool in the management of …
Whereas the search for small molecules against cytokine receptors has been abandoned due …

… This could be further refined with the future development of a βc-receptor antagonist which
… Th2 cytokine antagonists show promise for treating the causes of asthma and they may …

… are also promising. This could herald the first success for a chemokine receptor antagonist
as … that differ from other cytokines in that they act on seven transmembrane G protein-coupled …