PI3K/Akt/mTOR: A promising therapeutic target for non-medullary thyroid carcinoma

MS Petrulea, TS Plantinga, JW Smit… - Cancer treatment …, 2015 - Elsevier
… that this pathway may represent a promising target for systemic therapy in TC. The present
… For these reasons, efforts have been made to identify novel potential therapeutic targets for …

EZH2 in bladder cancer, a promising therapeutic target

M Martínez-Fernández, C Rubio, C Segovia… - International journal of …, 2015 - mdpi.com
… They are both considered promising therapeutic agents against various cancer types
including prostate, pancreas, gastric, breast, and lung cancer, and their combination causes …

Phospholamban: a promising therapeutic target in heart failure?

AG Schmidt, I Edes, EG Kranias - Cardiovascular drugs and therapy, 2001 - Springer
… protein, phospholamban, as potential therapeutic targets. We summarize structural and genetic
… /SR Ca2+ ATPase interaction may be a promising therapeutic approach for heart failure. …

MiRNA: Involvement of the MAPK pathway in ischemic stroke. A promising therapeutic target

A Gugliandolo, S Silvestro, C Sindona, P Bramanti… - Medicina, 2021 - mdpi.com
therapeutic strategies are being tested in order to discover novel therapeutic targets, to limit
… order to use them as diagnostic and prognostic markers or as a potential therapeutic target. …

Cell membrane as a promising therapeutic target: from materials design to biomedical applications

X Wu, JJ Hu, J Yoon - Angewandte Chemie, 2024 - Wiley Online Library
… , aid in designing therapeutic agents with improved outcomes. Thus, the cell membrane
is now recognized as an efficient and promising therapeutic target. Precise cell membrane …

Angiogenesis: a promising therapeutic target for ovarian cancer

A Bamias, S Pignata, E Pujade-Lauraine - Critical reviews in oncology …, 2012 - Elsevier
… Apart from VEGF other angiogenesis-related factors also represent promising therapeutic
targets in cancer therapy. Platelet-derived growth factor (PDGF) is essential to pericyte …

HER2/neu in Endometrial Cancer: A Promising Therapeutic Target With Diagnostic Challenges

N Buza, DM Roque, AD Santin - Archives of Pathology …, 2014 - meridian.allenpress.com
promising therapeutic target. Case reports have already shown clinical response to trastuzumab,
a humanized monoclonal immunoglobulin (Ig) G1 antibody against HER2, and patients …

Platelets in cardiac ischaemia/reperfusion injury: a promising therapeutic target

M Ziegler, X Wang, K Peter - Cardiovascular research, 2019 - academic.oup.com
… Their direct inhibition as well as their use as epitopes for site-directed therapy is a unique
and promising therapeutic approach for the prevention of I/R injury and ultimately the …

Metabolite sensing GPCRs: promising therapeutic targets for cancer treatment?

J Cosín-Roger, D Ortiz-Masia, MD Barrachina… - Cells, 2020 - mdpi.com
… , or genetic manipulations have revealed promising results in particular neoplastic contexts,
… and complicates their definition as potential therapeutic targets. Probably because of this, …

A review of Dynamin 2 involvement in cancers highlights a promising therapeutic target

D Trochet, M Bitoun - Journal of experimental & clinical cancer research, 2021 - Springer
Dynamin 2 (DNM2) is an ubiquitously expressed large GTPase well known for its role in
vesicle formation in endocytosis and intracellular membrane trafficking also acting as a …