Exploring the complex relationship between diabetes and cardiovascular complications: understanding diabetic cardiomyopathy and promising therapies

N Ghosh, L Chacko, H Bhattacharya, J Vallamkondu… - Biomedicines, 2023 - mdpi.com
… of diabetic cardiomyopathy (DCM). DCM involves several downstream cascades that cause
structural and functional alterations of the diabetic … , and subsequent heart failure over time. …

Are targeted therapies for diabetic cardiomyopathy on the horizon?

M Tate, DJ Grieve, RH Ritchie - Clinical Science, 2017 - portlandpress.com
… However, given the comparable effects of statins between diabetic and non-diabetic
individuals, as well as promising experimental data, treating the underlying myocardial lipotoxicity …

Diabetic cardiomyopathy: molecular mechanisms, detrimental effects of conventional treatment, and beneficial effects of natural therapy

B Parim, VV Sathibabu Uddandrao, G Saravanan - Heart Failure Reviews, 2019 - Springer
Diabetic complications are among the largely exigent health problems currently. … complications,
including diabetic cardiomyopathy (DCM), account for more than 80% of diabetic deaths. …

[HTML][HTML] Diabetic cardiomyopathy: current and future therapies. Beyond glycemic control

G Borghetti, D Von Lewinski, DM Eaton… - Frontiers in …, 2018 - frontiersin.org
… This review summarizes the pathogenesis of diabetic cardiomyopathy… , as well as both current
and potential future therapies. … promising new direction for treating diabetic patients. These …

Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence

Y Tan, Z Zhang, C Zheng, KA Wintergerst… - Nature Reviews …, 2020 - nature.com
… the development of diabetic cardiomyopathy and heart failure in type 1 and type 2 diabetes
mellitus, … therapeutic strategies for the treatment and prevention of diabetic cardiomyopathy. …

The mystery of diabetic cardiomyopathy: from early concepts and underlying mechanisms to novel therapeutic possibilities

P Grubić Rotkvić, Z Planinić, AM Liberati Pršo… - International journal of …, 2021 - mdpi.com
Diabetic patients are predisposed to diabetic cardiomyopathy, a specific form of cardiomyopathy
which is characterized by the development of myocardial fibrosis, cardiomyocyte …

[HTML][HTML] Current status on the therapeutic strategies for heart failure and diabetic cardiomyopathy

AH Kim, JE Jang, J Han - Biomedicine & Pharmacotherapy, 2022 - Elsevier
heart failure, to include both heart failure with reduced ejection fraction (HFrEF) and heart
failure … , while also diving further into heart failure and its correlation with diabetes and diabetic

Therapeutic potential of targeting oxidative stress in diabetic cardiomyopathy

NJ Byrne, NS Rajasekaran, ED Abel… - Free Radical Biology and …, 2021 - Elsevier
… hypertension, diabetes mellitus (DM) may increase the risk for heart failure development. …
induced by diabetes in the heart, a cardiac entity termed diabetic cardiomyopathy (DbCM). …

[HTML][HTML] Novel approaches in the treatment of diabetic cardiomyopathy

D Sivasankar, M George, DK Sriram - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Cardiomyopathy (CM), one among the many … of diabetes, we call it as Diabetic Cardiomyopathy
(DCM), the structural and functional abnormality of the myocardium in diabetic patients …

Myocardial metabolism in diabetic cardiomyopathy: potential therapeutic targets

MM Sung, SM Hamza, JRB Dyck - Antioxidants & redox signaling, 2015 - liebertpub.com
diabetes, may represent a safe and promising supplement to currently recommended clinical
therapy … initiation and progression of diabetic cardiomyopathy is essential for development …