… do enhancers select cognate promoters over non-cognate ones? Here, we define enhancer
selectivity … at cognate promoters over non-cognate promoters owing to the impact of a given …

… enhancers activate only the nearest promoter, recent global analyses enabled by high-throughput
technology suggest that the network of enhancer–promoter interactions is … selectivity (…

… Together, both datasets indicate that across multiple cell types and mammalian genomes,
enhancers and promoters are broadly compatible and there is an additional layer of selectivity …

… -enhancers (SEs). We identify a previously overlooked pattern (Variable pattern, Var) that
multiple enhancers … contains Shared enhancers with stable enhancer-promoter interactions in …

… to generate high-confidence enhancer–promoter RNA interaction maps in six …
enhancer–promoter RNA interaction sites are overlapped with Alu sequences. These pairwise …

… % of enhancers in our study did not interact with the promoters of … forebrain enhancer strongly
interacts with the promoter of … This raises the question: how is this E–P selectivity achieved…

… features of regulatory interactions We annotated enhancer–promoter interactions in six … rich
functional genomics data as well as high-resolution interaction data generated by Rao et al. : …

… ability of these enhancers to function on either gene. Our results reveal that both selectivity
and competition between promoters, in addition to the sharing of enhancer elements, are …

… play a major role in regulating E–P selectivity. Taken together, our data indicate that … of
enhancer-promoter interaction frequency between active and inactive tissues for brain enhancers …

… We found that more than half of the active cCREs exhibit significant selectivity for specific
subsets of promoters. We dissected some of the underlying sequence determinants. …