Pirfenidone and nintedanib modulate properties of fibroblasts and myofibroblasts in idiopathic pulmonary fibrosis
ST Lehtonen, A Veijola, H Karvonen… - Respiratory …, 2016 - Springer
… Fibroblasts and myofibroblasts are the key cells in the fibrotic process. Recently two drugs,
pirfenidone and nintedanib, were … the effects of pirfenidone and nintedanib on fibroblasts and …
pirfenidone and nintedanib, were … the effects of pirfenidone and nintedanib on fibroblasts and …
A novel antifibrotic mechanism of nintedanib and pirfenidone. Inhibition of collagen fibril assembly
L Knüppel, Y Ishikawa, M Aichler… - American journal of …, 2017 - atsjournals.org
… of HSP47 and FKBP10 by nintedanib and pirfenidone in IPF and donor fibroblasts. Notably,
… the effect of nintedanib and pirfenidone on fibroblast and myofibroblast properties and also …
… the effect of nintedanib and pirfenidone on fibroblast and myofibroblast properties and also …
Evaluation of pirfenidone and nintedanib in a human lung model of fibrogenesis
KM Roach, E Castells, K Dixon, S Mason… - Frontiers in …, 2021 - frontiersin.org
… The reduction in fibroblast-specific protein-positive cells with both pirfenidone and … effects
of nintedanib and pirfenidone in human lung tissue displaying early features of fibrosis after …
of nintedanib and pirfenidone in human lung tissue displaying early features of fibrosis after …
Differential effects of Nintedanib and Pirfenidone on lung alveolar epithelial cell function in ex vivo murine and human lung tissue cultures of pulmonary fibrosis
M Lehmann, L Buhl, HN Alsafadi, S Klee… - Respiratory …, 2018 - Springer
… Nintedanib has been shown to inhibit various fibroblast functions, such as proliferation, fibroblast
… /or effects on cells other than fibroblasts could contribute to the anti-fibrotic properties of …
… /or effects on cells other than fibroblasts could contribute to the anti-fibrotic properties of …
Fibroblast–matrix interplay: Nintedanib and pirfenidone modulate the effect of IPF fibroblast‐conditioned matrix on normal fibroblast phenotype
G Epstein Shochet, L Wollin, D Shitrit - Respirology, 2018 - Wiley Online Library
… -fibrotic drugs nintedanib and pirfenidone on the CM–fibroblast … formation, nintedanib was
more effective than pirfenidone in … However, nintedanib at 100 nmol/L did not significantly …
more effective than pirfenidone in … However, nintedanib at 100 nmol/L did not significantly …
Interferon-γ enhances the antifibrotic effects of pirfenidone by attenuating IPF lung fibroblast activation and differentiation
TN Vu, X Chen, HD Foda, GC Smaldone… - Respiratory …, 2019 - Springer
… Treatment of IPF with pirfenidone or nintedanib does not stop ongoing fibrosis … fibroblasts
were used in this study as IPF-derived fibroblasts are known to display morphological features …
were used in this study as IPF-derived fibroblasts are known to display morphological features …
Anti-fibrotic effects of pirfenidone and rapamycin in primary IPF fibroblasts and human alveolar epithelial cells
M Molina-Molina, C Machahua-Huamani… - BMC pulmonary …, 2018 - Springer
… We wanted to test the effect of pirfenidone and rapamycin on tenascin-c in lung fibroblasts
from IPF patients treated with the pro-fibrotic factor TGF−β. As shown in Fig. 2a, b, we found …
from IPF patients treated with the pro-fibrotic factor TGF−β. As shown in Fig. 2a, b, we found …
Efficacy of pirfenidone and nintedanib in interstitial lung diseases other than idiopathic pulmonary fibrosis: a systematic review
… Pirfenidone and nintedanib are antifibrotic medications … with antifibrotic properties, such as
pirfenidone and nintedanib, may … on the efficacy of pirfenidone and nintedanib in ILDs other …
pirfenidone and nintedanib, may … on the efficacy of pirfenidone and nintedanib in ILDs other …
Histopathological and molecular analysis of idiopathic pulmonary fibrosis lungs from patients treated with pirfenidone or nintedanib
Y Zhang, KD Jones, N Achtar‐Zadeh, G Green… - …, 2019 - Wiley Online Library
… The objective of this study was to quantify the impact of pirfenidone or nintedanib treatment
… fibrosis, fibroblast foci and alveolar macrophages in untreated or pirfenidone- or nintedanib-…
… fibrosis, fibroblast foci and alveolar macrophages in untreated or pirfenidone- or nintedanib-…
[HTML][HTML] Pirfenidone and nintedanib attenuates pulmonary artery endothelial and smooth muscle cells transformations induced by IL-11
I Roger, P Montero, J Milara, J Cortijo - European Journal of Pharmacology, 2024 - Elsevier
… of nintedanib and pirfenidone on pulmonary artery endothelial and smooth muscle cell
remodeling induced by IL-11 in vitro. Our results show that nintedanib (NTD) and pirfenidone (…
remodeling induced by IL-11 in vitro. Our results show that nintedanib (NTD) and pirfenidone (…
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