A review of clinical trials of human papillomavirus prophylactic vaccines

JT Schiller, X Castellsagué, SM Garland - Vaccine, 2012 - Elsevier
… This article provides a broad overview of clinical trial results for the two licensed prophylactic
human papillomavirus (HPV) vaccines, Cervarix ® (GlaxoSmithKline Biologicals, Rixensart, …

Prophylactic human papillomavirus vaccines

DR Lowy, JT Schiller - The Journal of clinical investigation, 2006 - Am Soc Clin Investig
Human papillomavirus (HPV) infection causes virtually all cases of cervical cancer, the …
This Review examines prophylactic HPV subunit vaccines based on the ability of the viral L1 …

Prophylactic efficacy of a quadrivalent human papillomavirus (HPV) vaccine in women with virological evidence of HPV infection

Future II Study Group - The Journal of infectious diseases, 2007 - academic.oup.com
… The purpose of the present report is to address these questions by assessing the prophylactic
efficacy of the quadrivalent HPV vaccine in preventing CIN, VIN, VaIN, and anogenital …

A pooled analysis of continued prophylactic efficacy of quadrivalent human papillomavirus (Types 6/11/16/18) vaccine against high-grade cervical and external genital …

SK Kjaer, K Sigurdsson, OE Iversen… - Cancer prevention …, 2009 - AACR
Quadrivalent human papillomavirus (HPV) vaccine has been shown to provide protection
from HPV 6/11/16/18–related cervical, vaginal, and vulvar disease through 3 years. We …

Prophylactic vaccination against human papillomavirus infection and disease in women: a systematic review of randomized controlled trials

L Rambout, L Hopkins, B Hutton, D Fergusson - Cmaj, 2007 - Can Med Assoc
… In summary, our systematic review demonstrates that prophylactic HPV vaccination is
highly efficacious in preventing vaccine type-specific HPV infection and precancerous cervical …

Efficacy of a quadrivalent prophylactic human papillomavirus (types 6, 11, 16, and 18) L1 virus-like-particle vaccine against high-grade vulval and vaginal lesions: a …

EA Joura, S Leodolter, M Hernandez-Avila… - The Lancet, 2007 - thelancet.com
… women are often related to infection with human papillomavirus (HPV). These cancers are
… the effect of a prophylactic quadrivalent HPV vaccine on the incidence of these diseases. …

Longer term efficacy of a prophylactic monovalent human papillomavirus type 16 vaccine

A Rowhani-Rahbar, C Mao, JP Hughes, FB Alvarez… - Vaccine, 2009 - Elsevier
… To our knowledge, this study provides information on efficacy and immunogenicity after
the longest duration of follow-up for any prophylactic HPV L1 VLP vaccine. The results of this …

High sustained efficacy of a prophylactic quadrivalent human papillomavirus types 6/11/16/18 L1 virus-like particle vaccine through 5 years of follow-up

LL Villa, RLR Costa, CA Petta, RP Andrade… - British Journal of …, 2006 - nature.com
Human papillomavirus (HPV) causes cervical, vulvar, and vaginal cancers, precancerous …
We report data for the longest efficacy evaluation to date of a prophylactic HPV vaccine. In total…

Understanding and learning from the success of prophylactic human papillomavirus vaccines

JT Schiller, DR Lowy - Nature Reviews Microbiology, 2012 - nature.com
… An estimated 5% of human cancers are caused by human papillomavirus (HPV) infections,
and most of these cancers are of the cervix. Two prophylactic HPV vaccines that target the …

Next generation prophylactic human papillomavirus vaccines

JT Schiller, M Müller - The lancet oncology, 2015 - thelancet.com
… Two prophylactic vaccines for human papillomavirus (HPV) are licensed for use in many …
-like particles (VLPs) of L1, the major papillomavirus virion protein. VLPs self-assemble from 72 …