… been exploited to produce HPV L1 VLP subunit vaccines. The vaccines elicit high titres of …
achieved by these vaccines against incident HPV infection and HPV-associated ano-genital …

… HPV also causes anal, vaginal, vulvar, penile, and oropharyngeal cancer. Prophylactic
HPV vaccines based on … The HPV L1 VLP constitutes current prophylactic HPV vaccines. …

… Cervarix ® and Gardasil ® are two prophylactic HPV vaccines designed primarily for cervical
cancer prevention. Cervarix is effective against HPV-16, -18, -31, -33 and -45, the five most …

(VLPs) by the synthesis and selfassembly in vitro of the major virus capsid protein L1 has
transformed our prospects for preventing both benign and malignant HPV-associated genital …

… This Review examines prophylactic HPV subunit vaccines based on the ability of the viral
L1 capsid protein to form virus-like particles (VLPs) that induce high levels of neutralizing …

… Prophylactic HPV vaccines … the prophylactic HPV vaccines protect against cervical HPV
infection and cervical (pre-)cancer? and (2) what are the harms associated with being vaccinated…

… infection are expected to substantially reduce HPV-related disease burden. Prophylactic
HPV vaccines in late stages of clinical testing are composed of HPV L1 capsid protein that self-…

… for HPV vaccination and mainly focus on prophylactic vaccines and … delivery of the licensed
VLP vaccines or biosimilars—and … novel vaccine approaches based on L1 or L2 (the HPV …

… second-generation HPV vaccines that will provide broader protection against the HPV types
… that has been made in developing vaccines targeting the minor capsid protein of HPV, L2. …

… vaccination until 21 years of age, the age of screening. Parents making decisions about HPV
vaccination … HPV vaccination reduces the possibility of their daughter having an abnormal …