The impact of early prophylactic use of intravenous indomethacin on the incidence and
severity of periventricular-intraventricular hemorrhage and patent ductus arteriosus in 199
oxygen-requiring premature infants (≤ 1300 g birth weight) was prospectively investigated.
The trial was controlled, the infants were randomized, and the investigators were unaware of
the group assignments. Patients with minimal (grade I) or no periventricular-intraventricular
hemorrhage determined by prestudy echoencephalography were randomized within two …