[HTML][HTML] Drug metabolism within the brain changes drug response: selective manipulation of brain CYP2B alters propofol effects

JY Khokhar, RF Tyndale - Neuropsychopharmacology, 2011 - nature.com
manipulation, we investigated the functional consequences of inducing and inhibiting brain
CYP2B-mediated metabolism of propofol … model of propofol sedation to study the effects of …

Manipulation of the endocannabinoid system by a general anaesthetic

V Di Marzo - British journal of pharmacology, 2003 - Wiley Online Library
… by examining the sedative effects of propofol in these ‘FAAH-… , propofol and other substances
manipulating endocannabinoid … The possibility that substances selectively manipulating the …

The influence of manipulations to alter ambient GABA concentrations on the hypnotic and immobilizing actions produced by sevoflurane, propofol, and midazolam

K Nishikawa, K Kubo, H Obata, Y Yanagawa… - Neuropharmacology, 2011 - Elsevier
… and immobilizing actions of propofol and midazolam in mice, whereas manipulations of
ambient GABA concentrations minimally alter cellular and behavioral responses to sevoflurane. …

A neuroanatomical construct for the amnesic effects of propofol

RA Veselis, RA Reinsel, VA Feshchenko… - The Journal of the …, 2002 - pubs.asahq.org
Background This study was designed to identify neuroanatomical locations of propofol's
effects on episodic memory by producing minimal and maximal memory impairment during …

Dose-dependent effects of propofol on the central processing of thermal pain

RK Hofbauer, P Fiset, G Plourde… - The Journal of the …, 2004 - pubs.asahq.org
… In conclusion, our study shows a differential effect of propofol on pain-evoked activity in
different brain regions. Further, the data suggest that after loss of consciousness, some …

Suppression of central nervous system sodium channels by propofol

B Rehberg, DS Duch - The Journal of the American Society of …, 1999 - pubs.asahq.org
propofol effect on channel inactivation could not be studied. However, the IC ( 50 ) value for
propofol … In the study of propofol effects on glutamate release, propofol inhibited sodium flux …

Propofol at a subanesthetic dose may have abuse potential in healthy volunteers

JP Zacny, JL Lichtor, W Thompson… - Anesthesia & …, 1993 - journals.lww.com
propofol choosers if individuals chose propofol two or three times, and nonchoosers if they
chose propofol … Six subjects were choosers: four subjects chose propofol on all three choice …

Selective propofol injection into the M1 segment of the middle cerebral artery (MCA Wada test) reduces adverse effects and enhances the reliability of the Wada test …

M Fujii, S Miyachi, N Matsubara, T Kinkori… - World neurosurgery, 2011 - Elsevier
… METHODS:: For the MCA Wada test (17 patients), 7 or 8 mg of propofol was injected via a
microcatheter navigated into the M1 segment, and language function was evaluated by patient …

[HTML][HTML] The effects of propofol anaesthesia on molecular-enriched networks during resting-state and naturalistic listening

T Lawn, D Martins, O O'Daly, S Williams, M Howard… - Neuroimage, 2023 - Elsevier
… the inverse of its effects on the task negative DMN connectivity (Spindler et al., 2021). Future
work employing both methods as well as more selective manipulation of catecholaminergic …

[HTML][HTML] Dynamic change of global and local information processing in propofol-induced loss and recovery of consciousness

MM Monti, ES Lutkenhoff, M Rubinov… - PLoS computational …, 2013 - journals.plos.org
propofol-induced sedation and loss of consciousness, and the recovery of wakefulness. Our
main findings, based on resting-state fMRI, are three-fold. First, we find that propofolpropofol-…