… findings in sheep that slower propofol administrations rates have minimal effect on propofol
concentrations in the brain but decrease arterial concentrations and the degree of propofol-…

… the effect of rapid and slow injection rates of propofol in sheep … injection caused higher
concentrations of propofol in the blood … , there may be little advantage in injecting propofol rapidly. …

… Twenty-four hours later the sheep were anaesthetized with PRF (6 mg/kg intravenous (IV)
followed by a continuous infusion at a rate of 0.4 mg/kg/min for 60 min) and cardiopulmonary …

… The infusion rate of propofol to maintain surgical anesthesia in this study was 0.49 ? 0.20
mg/kg/min. Alon et all0 reported that continuous infusion of 0.30 mg/kg/min of …

… responses in the sheep appear similar to those in man, the parallel changes in cerebral
blood flow and metabolic rate demonstrated in this study supports the suitability of propofol as a …

… Effects of propofol (open panels) or diiopentone (hatched panels) anaesthesia on heart
rate and mean arterial pressure in the sheep. To facilitate comparisons in this and accom…

… Consider the case where propofol is injected at a constant rate over a period T (eg 20 s) into
the peripheral venous circulation to produce a square wave concentration peak of duration T…

… rate of degradation of propofol by hepatic microsomes at any propofol concentration between
rats and sheep. … & 48.9 ą 2.2 for propofol in rat preparations and 0.43 ą 0.06 & 42.4 ą7.1 for …

… effects of high-dose lidocaine given as a CRI in combination with a propofol/fentanyl regimen
in sheep … The reduction of the propofol dose by 25% in conjunction with a lidocaine CRI …

… very close agreement between the effects of the rate of propofol administration on induction
… after bolus administration of propofol are similar between sheep and humans, and that the …