… Key search terms included Diprivan, propofol, and propofol infusion syndrome. Case
reports and small case series evaluating the use and toxicity of propofol in sedating critically ill …

… In 1999, the manufacturer completed a comprehensive safety review of all adverse events
in paediatric ICU patients receiving propofol reported to their database, which holds all reports …

… the use of propofol infusions involving 327 patients in a paediatric intensive care unit in the
US … metabolic acidosis developing in patients who were not critically ill on high dose propofol …

… half-life data for patients sedated with propofol for 3 days. In this study we have measured the
… steady state propofol concentrations during sedative infusions and the decline in propofol …

… patients received a median total cumulative propofol dose of … the median cumulative dose
of propofol received was 276.5 … a lower infusion dose and lower cumulative dose. Moreover, …

… Studies using continuous infusions to supplement regional anaesthesia have been … infusion
in the intensive care unit. We have used propofol in this way to provide sedation for patients …

… in all ICU patients treated with propofol in addition to the discontinuation of propofol if …
Although PRIS is associated with a high mortality rate and propofol is widely used in the ICU…

… clinical signs were correlated to patient diseases or to the critically ill status of the patient. …
effects, the use of propofol for long-term sedation in critically ill patients should be reconsidered.…

… should automatically be suspected if any of the signs of PRIS appear without alternative
explanation in an ICU patient on propofol infusion. There is no specific treatment for PRIS and …

… to increased patient morbidity and mortality. As critically ill patients receive numerous drugs
to … for the optimal management of critical illness, and propofol, a common sedative, has many …