[HTML][HTML] Clinical importance of potential genetic determinants affecting propofol pharmacokinetics and pharmacodynamics

I Budic, T Jevtovic Stoimenov, D Pavlovic… - Frontiers in …, 2022 - frontiersin.org
… on propofol pharmacokinetics after a single intravenous dosage, whereas UGT1A9 and
CYP2B6 SNPs, other clinical … is a separate factor that influences propofol pharmacokinetics (40). …

[HTML][HTML] Clinical pharmacokinetics and pharmacodynamics of propofol

MM Sahinovic, MMRF Struys, AR Absalom - Clinical pharmacokinetics, 2018 - Springer
… in real time can aid clinicians in optimal drug dosing while … of propofol in order to refresh
readers’ knowledge of its clinical … (cardiac output being one of the most important factors) and …

Impact of clinical factors and UGT1A9 and CYP2B6 genotype on inter-individual differences in propofol pharmacokinetics

A Kanaya, T Sato, N Fuse, H Yamaguchi, N Mano… - Journal of …, 2018 - Springer
… to identify factors determining propofol pharmacokinetics. … that BMI influences propofol
pharmacokinetics after its … and CYP2B6 SNPs, other clinical factors, and hemodynamic variables …

Population pharmacokinetics of propofol: a multicenter study

J Schüttler, H Ihmsen - The Journal of the American Society of …, 2000 - pubs.asahq.org
… In this study we performed a population pharmacokinetic analysis … to estimate the
pharmacokinetics of propofol with special … error may be considered a limiting factor for …

Influence of formulation on propofol pharmacokinetics and pharmacodynamics in anesthetized patients

R Calvo, S Telletxea, N Leal, L Aguilera… - Acta …, 2004 - Wiley Online Library
propofol and corresponding NONMEM FOCE objective functions (−2LLD) for pharmacokinetics
of propofol … V, apart from other factors, reflects the complexity of propofol independently of …

[HTML][HTML] Clinical factors affecting the pain on injection of propofol

HJ Kang, MY Kwon, BM Choi, MS Koo… - Korean journal of …, 2010 - synapse.koreamed.org
… on propofol injection is a well-known adverse effect. We evaluated the clinical factors that affect
the pain on injection of propofolclinical factors affecting the incidence of pain on propofol

The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers

TW Schnider, CF Minto, PL Gambus… - The Journal of the …, 1998 - pubs.asahq.org
… The influence of age on propofol pharmacokinetics remains … The influence of EDTA on the
pharmacokinetics of propofol has not been … before release of the new formulation of propofol. …

Pharmacokinetic models for propofol—defining and illuminating the devil in the detail

AR Absalom, V Mani, T De Smet… - British journal of …, 2009 - academic.oup.com
… can be programmed with any pharmacokinetic model, and allow … Marsh and Schnider
pharmacokinetic models for propofol. The … during combined pharmacokinetic–pharmacodynamic …

The pharmacokinetics of propofol in ICU patients undergoing long‐term sedation

P Smuszkiewicz, P Wiczling… - … & Drug Disposition, 2016 - Wiley Online Library
propofol administration for ICU patients still remain an open question. Although publications
on propofol pharmacokinetics … 4-9, the influence of different factors related to patients, their …

[HTML][HTML] Influence of clinical and genetic factors on propofol dose requirements: A genome-wide association study

S Ahlström, P Reiterä, R Jokela, KT Olkkola… - …, 2024 - pubs.asahq.org
… genes likely involved in propofol pharmacodynamics and pharmacokinetics have been
explored … Clinical Factors First, we investigated clinical factors predicting propofol requirements. …