… permeability factors in … proposed as a potential permeability factor by different groups: the
soluble urokinase plasminogen activator receptor (suPAR), cardiotrophin-like cytokine factor-1 (…

… We describe the history of the search for permeability factors, discuss the pitfalls that … propose
criteria that should be used in future studies when evaluating candidate permeability factors…

… , in particular for the optimization of leads and selection of development candidates. …
may be useful to illustrate key influencing factors for permeability. Not only will the diagnosis …

… permeability measurements employing in vitro techniques to aid in the design of oral drug
candidates… is dependent on a number of factors including first hepatic clearance and solubility/…

… LogP is a crucial factor governing passive membrane partitioning; an increase in LogP …
prediction of permeability for candidate compounds across a physiological lipid membrane. …

… ), drug transport mechanisms and factors affecting drug transportation across BBB along with
in vitro BBB models; and the approaches for evaluation of permeability of drug across BBB. …

… in evaluating permeability/absorption of drug candidates during the drug candidate selection
… The predominant factor that regulates the passage of drugs across the gastrointestinal …

… of the permeability factor include cytotoxic … factor 1 (CLCF-1) as a candidate for the permeability
factor. Therapies specific to CLCF-1 include potential use of cytokine receptor-like factor (…

… factor that limits the permeability of … permeability values obtained from different researchers,
helping to discriminate between the permeation properties of different drug candidates, …

… failures in the clinic were predominantly due to these two factors (2). Subsequently, the … to
these two factors has decreased substantially (2). Yet, the persistence of candidate compound …