Plasma proprotein convertase subtilisin–kexin type 9 does not change during 24 h insulin infusion in healthy subjects and type 2 diabetic patients
PJWH Kappelle, G Lambert, RPF Dullaart - Atherosclerosis, 2011 - Elsevier
… Plasma LDL cholesterol and apolipoprotein B were lowered by insulin in healthy subjects …
in healthy subjects (P < 0.01). Plasma PCSK9 levels remained unchanged in healthy subjects (…
in healthy subjects (P < 0.01). Plasma PCSK9 levels remained unchanged in healthy subjects (…
Proprotein convertase subtilisin–kexin type 9 is elevated in proteinuric subjects: Relationship with lipoprotein response to antiproteinuric treatment
AJ Kwakernaak, G Lambert, MCJ Slagman… - Atherosclerosis, 2013 - Elsevier
… Comparison between healthy subjects and proteinuric subjects were tested using
independent T-tests for continuous variables and chi-squared tests for dichotomized variables. In …
independent T-tests for continuous variables and chi-squared tests for dichotomized variables. In …
Prediction of cardiovascular events with levels of proprotein convertase subtilisin/kexin type 9: A systematic review and meta-analysis
C Vlachopoulos, D Terentes-Printzios… - Atherosclerosis, 2016 - Elsevier
… The pooled RR of total CV events for subjects categorized in the highest tertile of baseline …
levels predicted total CV events only in apparently healthy subjects (RR = 1.13, 95% CI: 1.050…
levels predicted total CV events only in apparently healthy subjects (RR = 1.13, 95% CI: 1.050…
The proprotein convertases, 20 years later
NG Seidah - Proprotein Convertases, 2011 - Springer
… In 1984, the identification of the yeast convertase kexin (also … of the mammalian proprotein
convertases. Kexin cleaves the … kexin to the mammalian proprotein convertases? Answers to …
convertases. Kexin cleaves the … kexin to the mammalian proprotein convertases? Answers to …
[HTML][HTML] Fasting reduces plasma proprotein convertase, subtilisin/kexin type 9 and cholesterol biosynthesis in humans
JD Browning, JD Horton - Journal of lipid research, 2010 - ASBMB
… Here we investigated the relationship between plasma PCSK9 levels and the lathosterol-to-cholesterol
ratio, a marker of cholesterol biosynthesis, in 18 healthy subjects during a 48 h …
ratio, a marker of cholesterol biosynthesis, in 18 healthy subjects during a 48 h …
What lies ahead for the proprotein convertases?
NG Seidah - Annals of the new York Academy of Sciences, 2011 - Wiley Online Library
… For secretory proteins [the main subject of this review], processing events occur in distinct …
by one or more members of the proprotein convertase (PC) family of serine proteinases of the …
by one or more members of the proprotein convertase (PC) family of serine proteinases of the …
Proprotein convertases: lessons from knockouts
N Scamuffa, F Calvo, M Chrétien, NG Seidah… - The FASEB …, 2006 - Wiley Online Library
… (39) reported a case of PC1/3 deficiency in a human subject who was a compound … female
subject was reported (40). In addition to the shared phenotypes with the previous subject, this …
subject was reported (40). In addition to the shared phenotypes with the previous subject, this …
Circulating levels of proprotein convertase subtilisin/kexin type 9 and arterial stiffness in a large population sample: data from the Brisighella Heart Study
… Serum proprotein convertase subtilisin/kexin type 9 ( PCSK 9) level (ng/mL; mean, 95% CI)
in the … PCSK9 indicates proprotein convertase subtilisin/kexin type 9; SUA, serum uric acid. …
in the … PCSK9 indicates proprotein convertase subtilisin/kexin type 9; SUA, serum uric acid. …
Plasma proprotein convertase subtilisin kexin type 9 as a predictor of carotid atherosclerosis in asymptomatic adults
… This present study sample was confined to the 295 asymptomatic subjects (151 men and
144 women; age 53 ± 13 years [mean ± SD], range 28 to 77) in whom we had available serum (…
144 women; age 53 ± 13 years [mean ± SD], range 28 to 77) in whom we had available serum (…
Plasma proprotein convertase subtilisin/kexin type 9 is associated with Lp (a) in type 2 diabetic patients
Y Nekaies, B Baudin, S Kelbousi, M Sakly… - Journal of Diabetes and its …, 2015 - Elsevier
… -matched to 50 non diabetic healthy subjects (27 men and 23 … healthy subjects before the
study. Written consents were not possible in all cases because the majority of eligible subjects …
study. Written consents were not possible in all cases because the majority of eligible subjects …
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