Neurodegeneration by oxidative stress: a review on prospective use of small molecules for neuroprotection
E Singh, G Devasahayam - Molecular Biology Reports, 2020 - Springer
The intricate physiology of many Central Nervous System (CNS) disorders points towards
oxidative damages of neurons. Various studies have established that oxidative stress is a big …
oxidative damages of neurons. Various studies have established that oxidative stress is a big …
[HTML][HTML] Small Molecules—Prospective Novel HCMV Inhibitors
… The list of novel small molecules that might have anti-HCMV activity has grown in recent
years. In this short review, a selection of compounds in clinical trials and novel inhibitors …
years. In this short review, a selection of compounds in clinical trials and novel inhibitors …
Small molecules, big impact: 20 years of targeted therapy in oncology
… molecular targets and the growing knowledge of their cellular functions have led to the
development of small molecule … The future of small molecule inhibitors is promising as there is the …
development of small molecule … The future of small molecule inhibitors is promising as there is the …
[HTML][HTML] Small molecules targeting biological clock; a novel prospective for anti-cancer drugs
… It has been discovered that these small molecules can regulate … This review examines the
potential use of small molecules … of small-molecule clock modulators and their potential use in …
potential use of small molecules … of small-molecule clock modulators and their potential use in …
[HTML][HTML] Discovery of small molecule cancer drugs: successes, challenges and opportunities
… In this article, we will review the current state of cancer drug discovery and development,
focussing on small molecules that act on new molecular targets that represent therapeutic …
focussing on small molecules that act on new molecular targets that represent therapeutic …
Small molecule microarrays: recent advances and applications
M Uttamchandani, DP Walsh, SQ Yao… - Current opinion in …, 2005 - Elsevier
… from the prospective discovery of novel small-molecule ligands, to the study of biological
samples and macromolecules with specific activity profiles. More importantly, there is concerted …
samples and macromolecules with specific activity profiles. More importantly, there is concerted …
A prospective method to guide small molecule drug design
AT Johnson - Journal of Chemical Education, 2015 - ACS Publications
… into small molecule drug design in a prospective manner, prioritize new target molecules
for … can influence drug-like properties of small molecules during the drug discovery process. …
for … can influence drug-like properties of small molecules during the drug discovery process. …
[HTML][HTML] Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction
KR Simonetta, J Taygerly, K Boyle, SE Basham… - Nature …, 2019 - nature.com
… Here we report the prospective discovery and rational design of small molecule molecular
glues that enhance a substrate:ligase interaction to induce substrate degradation. These …
glues that enhance a substrate:ligase interaction to induce substrate degradation. These …
Small-molecule inhibitors of tankyrases as prospective therapeutics for cancer
M Yu, Y Yang, M Sykes, S Wang - Journal of Medicinal Chemistry, 2022 - ACS Publications
… RK compounds emanated from a high-throughput screening of ∼140 000 small molecules
using fission yeast cells where overexpression of human tankyrase 1 induced a growth defect…
using fission yeast cells where overexpression of human tankyrase 1 induced a growth defect…
Oral small molecules for the treatment of atopic dermatitis: a systematic review
P Mobasher, MH Seradj, J Raffi, M Juhasz… - Journal of …, 2019 - Taylor & Francis
… oral small molecule medication for AD and written in English. Randomized clinical trials,
open-label prospective … the current literature surrounding the use of oral small molecules for AD. …
open-label prospective … the current literature surrounding the use of oral small molecules for AD. …
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